E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. (Q38847256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234678%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60 (English)

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20 February 2020

9

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20 February 2020

Sudhakar Jha

10

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20 February 2020

author name string

V K Subbaiah

1

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20 February 2020

Y Zhang

2

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20 February 2020

D Rajagopalan

3

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20 February 2020

L N Abdullah

4

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20 February 2020

N S L Yeo-Teh

5

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20 February 2020

V Tomaić

6

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20 February 2020

L Banks

7

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20 February 2020

M P Myers

8

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20 February 2020

language of work or name

English

0 references

publication date

3 August 2015

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20 February 2020

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20 February 2020

volume

35

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issue

16

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page(s)

2062-2074

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HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

20 February 2020

cites work

1 reference

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An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.

21 January 2018

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

21 January 2018

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Cellular functions of TIP60

21 January 2018

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Tip60 in DNA damage response and growth control: many tricks in one HAT.

21 January 2018

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Acetylation of histones and transcription-related factors

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Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage

21 January 2018

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RVB1/RVB2: running rings around molecular biology

21 January 2018

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Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions

21 January 2018

1 reference

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Estrogen receptor β (ERβ1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner

21 January 2018

1 reference

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Insulin-activated Elk-1 recruits the TIP60/NuA4 complex to increase prolactin gene transcription

21 January 2018

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DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

21 January 2018

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

21 January 2018

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Homozygous disruption of the Tip60 gene causes early embryonic lethality

21 January 2018

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Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

21 January 2018

1 reference

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TRIM29 negatively regulates p53 via inhibition of Tip60.

21 January 2018

1 reference

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KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling

21 January 2018

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A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence.

21 January 2018

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Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells

21 January 2018

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EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response

21 January 2018

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EDD mediates DNA damage-induced activation of CHK2

21 January 2018

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Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs

21 January 2018

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Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms

21 January 2018

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EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.

21 January 2018

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Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir

21 January 2018

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Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.

21 January 2018

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Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest

21 January 2018

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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions

21 January 2018

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Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.268

Tip60 acetylates six lysines of a specific class in core histones in vitro

21 January 2018

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Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.

21 January 2018

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Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response

21 January 2018

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

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Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.

21 January 2018

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Tip60: connecting chromatin to DNA damage signaling

21 January 2018

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Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

21 January 2018

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Inhibition of Bak-induced apoptosis by HPV-18 E6.

21 January 2018

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Putative tumor suppressor EDD interacts with and up-regulates APC

21 January 2018

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The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin

21 January 2018

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HECT and RING finger families of E3 ubiquitin ligases at a glance

21 January 2018

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The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity

21 January 2018

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

21 January 2018

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

21 January 2018

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Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs

21 January 2018

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

31 March 2020

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The MYST family of histone acetyltransferases.

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26234678

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26234678

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2015.268

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234678%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

1042775494

0 references

1 reference

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