Mechanistic diversity in ATP-binding cassette (ABC) transporters (Q38856661)

7 September 2017

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title

Mechanistic diversity in ATP-binding cassette (ABC) transporters (English)

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7 September 2017

Kaspar P Locher

1

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7 September 2017

publication date

1 June 2016

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Nature Structural & Molecular Biology

7 September 2017

published in

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7 September 2017

volume

23

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7 September 2017

issue

6

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7 September 2017

page(s)

487-493

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Structure, function, and evolution of bacterial ATP-binding cassette systems

7 September 2017

cites work

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ABC solute importers in bacteria

21 January 2018

1 reference

A structural classification of substrate-binding proteins

21 January 2018

1 reference

The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity

21 January 2018

1 reference

Lipid A modification systems in gram-negative bacteria

21 January 2018

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ABC transporters involved in export of cell surface glycoconjugates

21 January 2018

1 reference

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

21 January 2018

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Towards understanding promiscuity in multidrug efflux pumps

21 January 2018

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Molecular basis of multidrug transport by ABC transporters

21 January 2018

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ABC transporters involved in drug resistance in human parasites.

21 January 2018

1 reference

Plant ATP-binding cassette transporters

21 January 2018

1 reference

Multifunctionality of plant ABC transporters--more than just detoxifiers

21 January 2018

1 reference

Evolution of ABC transporters by gene duplication and their role in human disease

21 January 2018

1 reference

ABCC8 and ABCC9: ABC transporters that regulate K+ channels

21 January 2018

1 reference

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

21 January 2018

1 reference

CFTR function and prospects for therapy

21 January 2018

1 reference

The TAP translocation machinery in adaptive immunity and viral escape mechanisms

21 January 2018

1 reference

The transporter associated with antigen processing: a key player in adaptive immunity

21 January 2018

1 reference

Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system

21 January 2018

1 reference

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

The P-glycoprotein multidrug transporter.

21 January 2018

1 reference

Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer

21 January 2018

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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

21 January 2018

1 reference

Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts

21 January 2018

1 reference

Canalicular ABC transporters and liver disease

21 January 2018

1 reference

Lipid flopping in the liver

21 January 2018

1 reference

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

21 January 2018

1 reference

The controversial role of ABC transporters in clinical oncology.

21 January 2018

1 reference

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

21 January 2018

1 reference

Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.

21 January 2018

1 reference

Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter

21 January 2018

1 reference

The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation

21 January 2018

1 reference

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

21 January 2018

1 reference

Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism

21 January 2018

1 reference

Structural insights into ABC transporter mechanism

21 January 2018

1 reference

Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.

21 January 2018

1 reference

Perspectives on the structure-function of ABC transporters: the Switch and Constant Contact models

21 January 2018

1 reference

Structure of a Bacterial ABC Transporter Involved in the Import of an Acidic Polysaccharide Alginate

21 January 2018

1 reference

Structure of an ABC transporter in complex with its binding protein

21 January 2018

1 reference

Crystal structure of a catalytic intermediate of the maltose transporter

21 January 2018

1 reference

The ATP/substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA.

21 January 2018

1 reference

The allosteric regulatory mechanism of the Escherichia coli MetNI methionine ATP binding cassette (ABC) transporter

21 January 2018

1 reference

Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography

21 January 2018

1 reference

Recent insights into iron import by bacteria

21 January 2018

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ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12.

21 January 2018

1 reference

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F

21 January 2018

1 reference

Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F

21 January 2018

1 reference

Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking

21 January 2018

1 reference

Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF

21 January 2018

1 reference

Transmembrane gate movements in the type II ATP-binding cassette (ABC) importer BtuCD-F during nucleotide cycle

21 January 2018

1 reference

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

1 reference

Structure of a bacterial multidrug ABC transporter

21 January 2018

1 reference

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

21 January 2018

1 reference

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

21 January 2018

1 reference

Crystal structures of a polypeptide processing and secretion transporter

21 January 2018

1 reference

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

21 January 2018

1 reference

Mutational analysis of ABC proteins

21 January 2018

1 reference

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)

21 January 2018

1 reference

Multiple Drug Transport Pathways through Human P-Glycoprotein

21 January 2018

1 reference

Conformation of peptides bound to the transporter associated with antigen processing (TAP)

21 January 2018

1 reference

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

21 January 2018

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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

21 January 2018

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

21 January 2018

1 reference

Structure and mechanism of an active lipid-linked oligosaccharide flippase

21 January 2018

1 reference

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

21 January 2018

1 reference

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter

21 January 2018

1 reference

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

21 January 2018

1 reference

Asymmetric ATP hydrolysis cycle of the heterodimeric multidrug ABC transport complex TmrAB from Thermus thermophilus

21 January 2018

1 reference

Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin

21 January 2018

1 reference

A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer

21 January 2018

1 reference

Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.

21 January 2018

1 reference

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

21 January 2018

1 reference

A reciprocating twin-channel model for ABC transporters.

21 January 2018

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Membrane porters of ATP-binding cassette transport systems are polyphyletic

21 January 2018

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Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters

21 January 2018

1 reference

Watching conformational dynamics of ABC transporters with single-molecule tools

21 January 2018

1 reference

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

21 January 2018

1 reference

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications

21 January 2018

1 reference

Conformational Changes of the Antibacterial Peptide ATP Binding Cassette Transporter McjD Revealed by Molecular Dynamics Simulations

21 January 2018

1 reference

Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

21 January 2018

1 reference

Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways

21 January 2018

1 reference

Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (review).

21 January 2018

1 reference

ABC transporters: the power to change

21 January 2018

1 reference

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

21 January 2018

1 reference

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.

21 January 2018

1 reference

Structural diversity of ABC transporters.

21 January 2018

1 reference

Structure and mechanism of energy-coupling factor transporters

21 January 2018

1 reference

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

21 January 2018

1 reference

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

21 January 2018

1 reference

Structural Basis for Heavy Metal Detoxification by an Atm1-Type ABC Exporter

21 January 2018

1 reference

Refined structures of mouse P-glycoprotein

21 January 2018

1 reference

Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1

21 January 2018

1 reference

Flexibility in the ABC transporter MsbA: Alternating access with a twist

21 January 2018

1 reference

Review. Structure and mechanism of ATP-binding cassette transporters

21 January 2018

1 reference

Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis

21 January 2018

1 reference

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

21 January 2018

1 reference

The Resolution Revolution

21 January 2018

1 reference

Structure and mechanism of ABC transporters

21 January 2018

1 reference

Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27273632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overview of experimental models of the blood-brain barrier in CNS drug discovery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27273632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.3216

1 reference

7 September 2017

1 reference