Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans (Q27673547)

1

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Michael L Oldham

2

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Qiuju Zhang

3

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Jue Chen

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

4

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language of work or name

English

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publication date

25 October 2012

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published in

Nature

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volume

490

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page(s)

566-9

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issue

7421

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cites work

1 reference

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Alternating Access in Maltose Transporter Mediated by Rigid-Body Rotations

20 March 2017

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Structural insights into ABC transporter mechanism

20 March 2017

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Flexibility in the ABC transporter MsbA: Alternating access with a twist

20 March 2017

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Phasercrystallographic software

20 March 2017

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Version 1.2 of the Crystallography and NMR system

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The P-glycoprotein multidrug transporter.

20 March 2017

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Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis

29 September 2017

1 reference

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Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

29 September 2017

1 reference

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Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.

29 September 2017

1 reference

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Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein

29 September 2017

1 reference

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Discontinuous membrane helices in transport proteins and their correlation with function

29 September 2017

1 reference

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Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

29 September 2017

1 reference

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Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

29 September 2017

1 reference

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Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

29 September 2017

1 reference

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Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits

29 September 2017

1 reference

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

29 September 2017

1 reference

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Is the multidrug transporter a flippase?

29 September 2017

1 reference

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Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

29 September 2017

1 reference

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).

29 September 2017

1 reference

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Quantification and characterization of P-glycoprotein-substrate interactions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Absence of cooperativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482266

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23000902

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23000902

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11448

1 reference

Dimensions Publication ID

1712470

1033443248

0 references

1712470

1 reference

1 reference

1 reference