Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1. (Q38864019)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28363772%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1 (English)

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14 March 2020

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5

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14 March 2020

Patrick M. Sexton

4

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14 March 2020

author name string

Marlies V Hager

1

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14 March 2020

Lachlan Clydesdale

2

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14 March 2020

Samuel H Gellman

3

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14 March 2020

language of work or name

English

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publication date

29 March 2017

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14 March 2020

published in

Biochemical Pharmacology

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14 March 2020

volume

136

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14 March 2020

page(s)

99-108

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Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist

14 March 2020

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

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Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

27 July 2018

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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

27 July 2018

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Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

27 July 2018

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

27 July 2018

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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

27 July 2018

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Structural and biological mimicry of protein surface recognition by / -peptide foldamers

27 July 2018

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Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells

27 July 2018

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Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

27 July 2018

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Conformational complexity of G-protein-coupled receptors

27 July 2018

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Biology of incretins: GLP-1 and GIP

27 July 2018

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Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

27 July 2018

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Ligand-selective receptor conformations revisited: the promise and the problem

27 July 2018

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Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells

27 July 2018

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Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

27 July 2018

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Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview

27 July 2018

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β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.

27 July 2018

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A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus.

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A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo

22 August 2018

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Backbone modification of a polypeptide drug alters duration of action in vivo

22 August 2018

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22 August 2018

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22 August 2018

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22 August 2018

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Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes

22 August 2018

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Therapeutic potential of β-arrestin- and G protein-biased agonists.

22 August 2018

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

22 August 2018

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GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells

22 August 2018

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Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1.

22 August 2018

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Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

22 August 2018

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Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

22 August 2018

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Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

22 August 2018

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Conformational and biological characterization of human parathyroid hormone hPTH(1-34) analogues containing beta-amino acid residues in positions 17-19.

22 August 2018

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Metformin: new understandings, new uses

22 August 2018

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Structure-function studies of analogues of parathyroid hormone (PTH)-1-34 containing beta-amino acid residues in positions 11-13.

22 August 2018

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Beta-amino acids: versatile peptidomimetics

22 August 2018

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Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.

22 August 2018

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Operational models of pharmacological agonism.

22 August 2018

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Insulin therapy for type 2 diabetes

22 August 2018

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Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s)

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28363772

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A luminescent biosensor with increased dynamic range for intracellular cAMP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28363772

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BCP.2017.03.018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28363772%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28363772%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

28363772

1 reference