Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias. (Q38871799)

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14 March 2020

title

Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias (English)

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5

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Joan Antoni Schoenenberger

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10

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Mario Encinas

11

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Eloi Garí

12

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Xavier Dolcet

14

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Xavier Matias-Guiu Guia

13

object named as

Xavier Matias-Guiu

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author name string

Maria Alba Dosil

1

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Cristina Mirantes

2

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Núria Eritja

3

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Isidre Felip

4

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Sònia Gatius

6

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Maria Santacana

7

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Eva Colàs

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Cristian Moiola

9

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publication date

28 April 2017

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14 March 2020

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volume

242

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page(s)

152-164

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issue

2

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

14 March 2020

cites work

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PTEN: sometimes taking it off can be better than putting it on.

21 January 2018

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PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

21 January 2018

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Integrated genomic characterization of endometrial carcinoma

21 January 2018

1 reference

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

21 January 2018

1 reference

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.

21 January 2018

1 reference

21 January 2018

New roles of cyclin D1.

1 reference

Mice thrive without Cdk4 and Cdk2.

21 January 2018

1 reference

Cell cycle, CDKs and cancer: a changing paradigm

21 January 2018

1 reference

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer

21 January 2018

1 reference

Cyclins and CDKS in development and cancer: lessons from genetically modified mice

21 January 2018

1 reference

Cell cycle kinases in cancer

21 January 2018

1 reference

CDK inhibitors in cancer therapy: what is next?

21 January 2018

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Combinatorial therapy using dovitinib and ICI182.780 (fulvestrant) blocks tumoral activity of endometrial cancer cells

21 January 2018

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Effects of the multikinase inhibitors Sorafenib and Regorafenib in PTEN deficient neoplasias.

21 January 2018

1 reference

A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis.

21 January 2018

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Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth

21 January 2018

1 reference

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

21 January 2018

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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

21 January 2018

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PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

21 January 2018

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

21 January 2018

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

21 January 2018

1 reference

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

21 January 2018

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Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

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Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies.

21 January 2018

1 reference

Targeting cell cycle and hormone receptor pathways in cancer.

21 January 2018

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p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

21 January 2018

1 reference

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

21 January 2018

1 reference

The history and future of targeting cyclin-dependent kinases in cancer therapy

21 January 2018

1 reference

Targeting CDK4 and CDK6: From Discovery to Therapy

21 January 2018

1 reference

Palbociclib (PD0332991)-a Selective and Potent Cyclin-Dependent Kinase Inhibitor: A Review of Pharmacodynamics and Clinical Development

21 January 2018

1 reference

Patient-derived xenograft models: an emerging platform for translational cancer research

21 January 2018

1 reference

One mouse, one patient paradigm: New avatars of personalized cancer therapy

21 January 2018

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CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

21 January 2018

1 reference

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

21 January 2018

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Modification of the DNA damage response by therapeutic CDK4/6 inhibition

21 January 2018

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A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model.

21 January 2018

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A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

21 January 2018

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Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

21 January 2018

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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

21 January 2018

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4896

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14 March 2020

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