P2 receptors, microglial cytokines and chemokines, and neuropathic pain (Q38885571)

7 September 2017

1 reference

title

P2 receptors, microglial cytokines and chemokines, and neuropathic pain (English)

1 reference

7 September 2017

0 references

1 reference

Makoto Tsuda

1

1 reference

7 September 2017

4 July 2016

1 reference

Journal of Neuroscience Research

7 September 2017

1 reference

7 September 2017

95

1 reference

7 September 2017

1319-1329

1 reference

7 September 2017

6

1 reference

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

7 September 2017

1 reference

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

21 January 2018

1 reference

Sciatic chronic constriction injury produces cell-type-specific changes in the electrophysiological properties of rat substantia gelatinosa neurons.

21 January 2018

1 reference

Mechanisms of Disease: neuropathic pain—a clinical perspective

21 January 2018

1 reference

P2X4R+ microglia drive neuropathic pain

21 January 2018

1 reference

Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells

21 January 2018

1 reference

Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain

21 January 2018

1 reference

Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.

21 January 2018

1 reference

Physiology and pathophysiology of purinergic neurotransmission

21 January 2018

1 reference

Purinergic signalling and disorders of the central nervous system

21 January 2018

1 reference

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

21 January 2018

1 reference

The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats

21 January 2018

1 reference

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

21 January 2018

1 reference

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

21 January 2018

1 reference

P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

21 January 2018

1 reference

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

21 January 2018

1 reference

Neuropathic pain: a maladaptive response of the nervous system to damage

21 January 2018

1 reference

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

21 January 2018

1 reference

Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome

21 January 2018

1 reference

Glial role in oxaliplatin-induced neuropathic pain

21 January 2018

1 reference

Identification of spinal circuits transmitting and gating mechanical pain

21 January 2018

1 reference

Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain.

21 January 2018

1 reference

Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway.

21 January 2018

1 reference

Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin

21 January 2018

1 reference

Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch

21 January 2018

1 reference

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

21 January 2018

1 reference

G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity.

21 January 2018

1 reference

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

21 January 2018

1 reference

Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia

21 January 2018

1 reference

The inflammasome: an integrated view

21 January 2018

1 reference

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

21 January 2018

1 reference

Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.

21 January 2018

1 reference

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

21 January 2018

1 reference

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

21 January 2018

1 reference

Spinal P2X(7) receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model.

21 January 2018

1 reference

Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia

21 January 2018

1 reference

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat

21 January 2018

1 reference

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

21 January 2018

1 reference

Ionizing radiation induces astrocyte gliosis through microglia activation

21 January 2018

1 reference

Nucleotide signalling during inflammation

21 January 2018

1 reference

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

21 January 2018

1 reference

Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.

21 January 2018

1 reference

Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model.

21 January 2018

1 reference

Medicinal chemistry of adenosine, P2Y and P2X receptors

21 January 2018

1 reference

Emerging targets in neuroinflammation-driven chronic pain

21 January 2018

1 reference

Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT

21 January 2018

1 reference

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

21 January 2018

1 reference

Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

21 January 2018

1 reference

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

21 January 2018

1 reference

Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

21 January 2018

1 reference

P2X receptors as cell-surface ATP sensors in health and disease

21 January 2018

1 reference

Neuromodulation by extracellular ATP and P2X receptors in the CNS.

21 January 2018

1 reference

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

21 January 2018

1 reference

Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias

21 January 2018

1 reference

Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation

21 January 2018

1 reference

P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

21 January 2018

1 reference

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

21 January 2018

1 reference

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation

21 January 2018

1 reference

Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders.

21 January 2018

1 reference

The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12.

21 January 2018

1 reference

Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

21 January 2018

1 reference

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

21 January 2018

1 reference

Expression cloning of an ATP receptor from mouse neuroblastoma cells

21 January 2018

1 reference

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

21 January 2018

1 reference

Cancer pain and its impact on diagnosis, survival and quality of life

21 January 2018

1 reference

Role of the immune system in chronic pain.

21 January 2018

1 reference

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype

21 January 2018

1 reference

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

21 January 2018

1 reference

IRF8 is a transcriptional determinant for microglial motility

21 January 2018

1 reference

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia.

21 January 2018

1 reference

21 January 2018

1 reference

Current challenges in glia-pain biology

21 January 2018

1 reference

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

21 January 2018

1 reference

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

21 January 2018

1 reference

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

21 January 2018

1 reference

Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers

21 January 2018

1 reference

P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

21 January 2018

1 reference

Molecular physiology of P2X receptors

21 January 2018

1 reference

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

21 January 2018

1 reference

Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation.

21 January 2018

1 reference

Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae

21 January 2018

1 reference

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

21 January 2018

1 reference

The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages.

21 January 2018

1 reference

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

21 January 2018

1 reference

Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia

21 January 2018

1 reference

Normal and abnormal coding of somatosensory stimuli causing pain

21 January 2018

1 reference

Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis

21 January 2018

1 reference

Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain

21 January 2018

1 reference

The trafficking and targeting of P2X receptors

21 January 2018

1 reference

Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain.

21 January 2018

1 reference

ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin.

21 January 2018

1 reference

21 January 2018

1 reference

The neuropathic pain triad: neurons, immune cells and glia

21 January 2018

1 reference

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

21 January 2018

1 reference

Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice

21 January 2018

1 reference

Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5

21 January 2018

1 reference

Direct observation of ATP-induced conformational changes in single P2X(4) receptors

21 January 2018

1 reference

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

21 January 2018

1 reference

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

21 January 2018

1 reference

Do glial cells control pain?

21 January 2018

1 reference

The IRF family transcription factors in immunity and oncogenesis

21 January 2018

1 reference

Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain.

21 January 2018

1 reference

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

21 January 2018

1 reference

CCL2 is a key mediator of microglia activation in neuropathic pain states

21 January 2018

1 reference

Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.

21 January 2018

1 reference

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin

21 January 2018

1 reference

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

21 January 2018

1 reference

P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

21 January 2018

1 reference

P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation

21 January 2018

1 reference

Microglia in the spinal cord and neuropathic pain

21 January 2018

1 reference

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

21 January 2018

1 reference

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

21 January 2018

1 reference

Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia

21 January 2018

1 reference

Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury.

21 January 2018

1 reference

Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury

21 January 2018

1 reference

Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays

21 January 2018

1 reference

IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain

21 January 2018

1 reference

Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways

21 January 2018

1 reference

Microglia and intractable chronic pain

21 January 2018

1 reference

Microglial regulation of neuropathic pain.

21 January 2018

1 reference

P2X4 receptors and neuropathic pain.

21 January 2018

1 reference

Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.

21 January 2018

1 reference

Molecular properties of ATP-gated P2X receptor ion channels

21 January 2018

1 reference

Activated microglia in the spinal cord underlies diabetic neuropathic pain

21 January 2018

1 reference

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

21 January 2018

1 reference

Glial activation: a driving force for pathological pain

21 January 2018

1 reference

Cloning and functional expression of a brain G-protein-coupled ATP receptor

21 January 2018

1 reference

Chemokines and the pathophysiology of neuropathic pain

21 January 2018

1 reference

Neuropathic pain: aetiology, symptoms, mechanisms, and management

21 January 2018

1 reference

Neuronal plasticity: increasing the gain in pain

21 January 2018

1 reference

Electroacupuncture Relieves Nerve Injury-Induced Pain Hypersensitivity via the Inhibition of Spinal P2X7 Receptor-Positive Microglia.

21 January 2018

1 reference

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

21 January 2018

1 reference

Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury

21 January 2018

1 reference

Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain

21 January 2018

1 reference

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

21 January 2018

1 reference

Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JNR.23816

1 reference

7 September 2017

1 reference

PubMed ID

27376880