CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes. (Q38890103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849141%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes (English)

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4 March 2020

3

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4 March 2020

Martin Dienstbier

5

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4 March 2020

author name string

Clélia Laitem

1

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4 March 2020

Justyna Zaborowska

2

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4 March 2020

Johann Kufs

4

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4 March 2020

Shona Murphy

6

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4 March 2020

publication date

6 April 2015

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Nature Structural & Molecular Biology

4 March 2020

published in

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4 March 2020

volume

22

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4 March 2020

issue

5

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4 March 2020

page(s)

396-403

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https://scigraph.springernature.com/pub.10.1038/nsmb.3000

4 March 2020

exact match

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Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.

9 September 2017

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The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

9 September 2017

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

9 September 2017

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Pre-mRNA 3'-end processing complex assembly and function

9 September 2017

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Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome

9 September 2017

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9 September 2017

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9 September 2017

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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.

9 September 2017

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RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress

14 September 2017

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3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

14 September 2017

1 reference

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Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes

17 June 2018

1 reference

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DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation

17 June 2018

1 reference

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P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

17 June 2018

1 reference

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CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II.

17 June 2018

1 reference

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Tracking rates of transcription and splicing in vivo.

22 August 2018

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Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript

22 August 2018

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22 August 2018

Identifiers

DOI

10.1038/NSMB.3000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849141%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

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4 March 2020

PubMed publication ID

25849141

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849141%20AND%20SRC:MED&resulttype=core&format=json