Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways. (Q38910507)

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29 February 2020

title

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways (English)

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29 February 2020

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7

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4

Richard Elliott

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29 February 2020

author name string

Marieke Aarts

1

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29 February 2020

Ilirjana Bajrami

2

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Maria T Herrera-Abreu

3

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Rachel Brough

5

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Nicholas C Turner

8

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Alan Ashworth

6

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publication date

11 February 2015

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Molecular Cancer Therapeutics

29 February 2020

published in

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volume

14

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issue

4

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page(s)

865-876

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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

29 February 2020

cites work

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12 December 2020

Cell-cycle checkpoints and cancer

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12 December 2020

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis

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12 December 2020

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

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12 December 2020

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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12 December 2020

Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase

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12 December 2020

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

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12 December 2020

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

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12 December 2020

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

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12 December 2020

ATR activation and replication fork restart are defective in FANCM-deficient cells

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12 December 2020

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

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12 December 2020

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

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12 December 2020

The FANCM family of DNA helicases/translocases.

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12 December 2020

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

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12 December 2020

Targeting Chk1 in the replicative stress response

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12 December 2020

MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM

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12 December 2020

Susceptibility pathways in Fanconi's anemia and breast cancer

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12 December 2020

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

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12 December 2020

Mutations of the SLX4 gene in Fanconi anemia

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12 December 2020

FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair

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12 December 2020

WEE1 inhibition sensitizes osteosarcoma to radiotherapy

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12 December 2020

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates.

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12 December 2020

DNA interstrand crosslink repair and cancer

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12 December 2020

MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.

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12 December 2020

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

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12 December 2020

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

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12 December 2020

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

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12 December 2020

Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines

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12 December 2020

BRCA1 and BRCA2: different roles in a common pathway of genome protection

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12 December 2020

The DNA translocase activity of FANCM protects stalled replication forks

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12 December 2020

Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.

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12 December 2020

Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo

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12 December 2020

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

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12 December 2020

Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.

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12 December 2020

Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

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12 December 2020

WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas

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12 December 2020

Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response

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12 December 2020

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

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12 December 2020

Tumour selective targeting of cell cycle kinases for cancer treatment

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12 December 2020

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy

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12 December 2020

WEE1 inhibition and genomic instability in cancer

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12 December 2020

Heterozygous mutations in PALB2 cause DNA replication and damage response defects

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12 December 2020

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

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12 December 2020

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

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12 December 2020

Identification of the breast cancer susceptibility gene BRCA2

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12 December 2020

10.1158/1535-7163.MCT-14-0845

Identifiers

DOI

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29 February 2020

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29 February 2020

PubMed publication ID

25673822

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