Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis (Q38911151)

8 October 2017

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis (English)

1 reference

8 October 2017

Plasmodium falciparum

0 references

1 reference

Alan Brown

5

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Xiao-chen Bai

Xiao-Chen Bai

2

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Brad E Sleebs

Brad E Sleebs

3

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Eric Hanssen

Eric Hanssen

8

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Alan Frederick Cowman

12

Alan F Cowman

1 reference

8 October 2017

Stuart A Ralph

11

0 references

Tony Triglia

4

Tony Triglia

1 reference

8 October 2017

13

Sjors H W Scheres

1 reference

8 October 2017

9

Danushka S Marapana

1 reference

8 October 2017

14

Jake Baum

1 reference

8 October 2017

Wilson Wong

1

1 reference

8 October 2017

Jennifer K Thompson

6

1 reference

8 October 2017

Katherine E Jackson

7

1 reference

8 October 2017

Israel S Fernandez

10

1 reference

8 October 2017

13 March 2017

1 reference

8 October 2017

1 reference

8 October 2017

2

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8 October 2017

17031

1 reference

https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.31

8 October 2017

0 references

cites work

Neuropsychiatric Adverse Reactions to Mefloquine: a Systematic Comparison of Prescribing and Patient Safety Guidance in the US, UK, Ireland, Australia, New Zealand, and Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Dynamical features of the Plasmodium falciparum ribosome during translation.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Malaria medicines: a glass half full?

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Structure of the human 80S ribosome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Decreasing pfmdr1 copy number suggests that Plasmodium falciparum in Western Cambodia is regaining in vitro susceptibility to mefloquine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Structure of the large ribosomal subunit from human mitochondria.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Structural basis for the inhibition of the eukaryotic ribosome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

The structure of the eukaryotic ribosome at 3.0 Å resolution

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Thousands of chemical starting points for antimalarial lead identification

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Transporters as mediators of drug resistance in Plasmodium falciparum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Antimalarials. 7. Bis(trifluoromethyl)-.alpha.-(2-piperidyl)-4-quinolinemethanols

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Developmental regulation of stage-specific ribosome populations in Plasmodium

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

The in vitro and in vivo effects of mefloquine on Trypanosoma brucei brucei

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5439513

Accurate determination of local defocus and specimen tilt in electron microscopy

22 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

RELION: implementation of a Bayesian approach to cryo-EM structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Beam-induced motion correction for sub-megadalton cryo-EM particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

21 January 2018

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

inferred from DOI database lookup

7 January 2021

based on heuristic

Quantifying the local resolution of cryo-EM density maps

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

REFMAC5 for the refinement of macromolecular crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Low-resolution refinement tools in REFMAC5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Correcting pervasive errors in RNA crystallography through enumerative structure prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMICROBIOL.2017.31

10.1038/NMICROBIOL.2017.31

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

8 October 2017

0 references

1 reference

8 October 2017

1 reference