LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling (Q38912642)

7 September 2017

title

LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling (English)

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7 September 2017

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Fei Niu

1

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7 September 2017

Yan Li

2

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7 September 2017

Fang-Fang Lai

3

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7 September 2017

Lin Ni

4

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7 September 2017

Ming Ji

5

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7 September 2017

Jing Jin

6

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7 September 2017

Han-Ze Yang

7

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7 September 2017

Chao Wang

8

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7 September 2017

Dong-Ming Zhang

9

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7 September 2017

Xiao-Guang Chen

10

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7 September 2017

publication date

1 September 2015

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Journal of Cellular Physiology

7 September 2017

published in

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7 September 2017

volume

230

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7 September 2017

issue

9

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7 September 2017

page(s)

2212-2223

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7 September 2017

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trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells

21 January 2018

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Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

21 January 2018

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Hypoxia, gene expression, and metastasis

21 January 2018

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The pancreas cancer microenvironment

21 January 2018

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Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo

21 January 2018

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Hypoxia and angiogenesis in pancreatic cancer.

21 January 2018

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HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

21 January 2018

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Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

21 January 2018

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Triptolide functions as a potent angiogenesis inhibitor.

21 January 2018

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21 January 2018

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Activated STAT3 Regulates Hypoxia-Induced Angiogenesis and Cell Migration in Human Glioblastoma

21 January 2018

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Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

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Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

21 January 2018

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

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Triptolide: progress on research in pharmacodynamics and toxicology

21 January 2018

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Hypoxia: a key regulator of angiogenesis in cancer

21 January 2018

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Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

21 January 2018

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Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues

21 January 2018

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Molecular mechanisms of mTOR-mediated translational control

21 January 2018

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HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells

21 January 2018

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Inhibiting hypoxia-inducible factor 1 for cancer therapy

21 January 2018

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Mammalian target of rapamycin: a new molecular target for breast cancer

21 January 2018

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Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

21 January 2018

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Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways

21 January 2018

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Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

21 January 2018

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The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

21 January 2018

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Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues

21 January 2018

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STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

21 January 2018

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STAT3 or USF2 contributes to HIF target gene specificity

21 January 2018

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Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

21 January 2018

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A novel regulation of VEGF expression by HIF-1α and STAT3 in HDM2 transfected prostate cancer cells

21 January 2018

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

21 January 2018

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Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α.

21 January 2018

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Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer.

21 January 2018

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

21 January 2018

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Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation

21 January 2018

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

21 January 2018

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Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells.

21 January 2018

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Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24949

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7 September 2017

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