Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells (Q38943429)

7 September 2017

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells (English)

1 reference

7 September 2017

11

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7 June 2020

author name string

Wade Borcherds

1

1 reference

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7 June 2020

François-Xavier Theillet

2

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7 June 2020

Andrea Katzer

3

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7 June 2020

Ana Finzel

4

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7 June 2020

Katie M Mishall

5

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7 June 2020

Anne T Powell

6

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7 June 2020

Hongwei Wu

7

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7 June 2020

Wanda Manieri

8

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7 June 2020

Christoph Dieterich

9

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7 June 2020

Philipp Selenko

10

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7 June 2020

Gary W Daughdrill

12

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7 June 2020

publication date

2 November 2014

1 reference

7 September 2017

Nature Chemical Biology

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7 June 2020

volume

10

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7 June 2020

issue

12

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7 June 2020

page(s)

1000-1002

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https://scigraph.springernature.com/pub.10.1038/nchembio.1668

7 June 2020

exact match

0 references

cites work

Linking folding and binding

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Probing the diverse landscape of protein flexibility and binding

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Conformational entropy in molecular recognition by proteins

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Energetic basis of uncoupling folding from binding for an intrinsically disordered protein

21 January 2018

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p53 in health and disease

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The p53-mdm-2 autoregulatory feedback loop

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21 January 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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Dynamics of the p53-Mdm2 feedback loop in individual cells

21 January 2018

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NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

21 January 2018

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Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

21 January 2018

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Structural Ensemble of an Intrinsically Disordered Polypeptide

21 January 2018

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Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

21 January 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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p53 dynamics control cell fate

21 January 2018

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The antioxidant function of the p53 tumor suppressor

21 January 2018

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Distinct mechanisms act in concert to mediate cell cycle arrest

21 January 2018

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NMR View: A computer program for the visualization and analysis of NMR data

21 January 2018

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Sequence-specific random coil chemical shifts of intrinsically disordered proteins

21 January 2018

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Sequence-dependent correction of random coil NMR chemical shifts

21 January 2018

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Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts.

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Activation and control of p53 tetramerization in individual living cells

21 January 2018

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Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

21 January 2018

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

21 January 2018

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Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

21 January 2018

1 reference

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Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

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Helical Propensity in an Intrinsically Disordered Protein Accelerates Ligand Binding

21 January 2018

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In vivo ubiquitination and proteasome-mediated degradation of p53(1)

21 January 2018

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

A third-generation lentivirus vector with a conditional packaging system

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12 December 2020

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7 January 2021

inferred from DOI database lookup

Determinants of specificity of MDM2 for the activation domains of p53 and p65: proline27 disrupts the MDM2-binding motif of p53

1 reference

12 December 2020