Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. (Q38979235)

8 September 2017

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title

Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. (English)

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Streptomyces griseochromogenes

8 September 2017

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inferred from

reverse claim

[(16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl] 3-hydroxy-3-(4-methyl-2,5-dioxofuran-3-yl)propanoate

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Si-Sun Choi

1

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8 September 2017

Hee-Ju Nah

series ordinal

2

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8 September 2017

Hye-Rim Pyeon

series ordinal

3

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8 September 2017

Eung-Soo Kim

series ordinal

4

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8 September 2017

publication date

12 October 2016

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Journal of Industrial Microbiology & Biotechnology

8 September 2017

published in

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8 September 2017

volume

44

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8 September 2017

issue

4-5

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8 September 2017

page(s)

555-561

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Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta

8 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

T Cell-specific immunosuppression using tautomycetin or PTD-conjugated protein drugs

21 January 2018

1 reference

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Natural products with maleic anhydride structure: nonadrides, tautomycin, chaetomellic anhydride, and other compounds

21 January 2018

1 reference

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Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Tautomycetin as a novel immunosuppressant in transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-streptomyces artificial chromosome vector, pSBAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

SHP2 is a target of the immunosuppressant tautomycetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Differential effects of tautomycetin and its derivatives on protein phosphatase inhibition, immunosuppressive function and antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1847-2

The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model

21 January 2018

1 reference

12 December 2020

Immunosuppressive agents in organ transplantation: past, present, and future

1 reference

12 December 2020

A new antibiotic, tautomycetin

1 reference

12 December 2020

A new antibiotic, tautomycin

1 reference

12 December 2020

Structure and function of a novel PP-1 specific inhibitor, tautomycetin

1 reference

12 December 2020

Antifungal activity of tautomycin and related compounds against Sclerotinia sclerotiorum

1 reference

12 December 2020

Immunosuppressive agents: recent developments in molecular action and clinical application

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12 December 2020

Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412

1 reference

12 December 2020

10.1007/S10295-016-1847-2

Identifiers

DOI

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8 September 2017

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