Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals (Q38980557)

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English	Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals	scientific article

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scholarly article

1 reference

Europe PubMed Central

8 September 2017

Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals (English)

1 reference

Europe PubMed Central

8 September 2017

0 references

neoplastic stem cells

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Sushil Kumar

1

1 reference

Europe PubMed Central

8 September 2017

Komal Raina

2

1 reference

Europe PubMed Central

8 September 2017

Chapla Agarwal

3

1 reference

Europe PubMed Central

8 September 2017

Rajesh Agarwal

4

1 reference

Europe PubMed Central

8 September 2017

language of work or name

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publication date

1 July 2014

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Europe PubMed Central

8 September 2017

1 reference

Europe PubMed Central

8 September 2017

5

1 reference

Europe PubMed Central

8 September 2017

4972-4989

1 reference

Europe PubMed Central

8 September 2017

13

1 reference

Europe PubMed Central

8 September 2017

A 3D multiscale model of cancer stem cell in tumor development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Epithelial interleukin-4 receptor expression promotes colon tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Natural products and colon cancer: current status and future prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Stem cells and solid cancers

1 reference

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9 September 2017

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

1 reference

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9 September 2017

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

1 reference

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9 September 2017

Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats

1 reference

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Crypt stem cells as the cells-of-origin of intestinal cancer

1 reference

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Emerging role of Notch in stem cells and cancer

1 reference

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Colon cancer stem cells: implications for prevention and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

1 reference

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WNT signaling in stem cell biology and regenerative medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Human colon cancer stem cells: a new paradigm in gastrointestinal oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Bmi1 is expressed in vivo in intestinal stem cells

1 reference

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9 September 2017

Crucial role of interleukin-4 in the survival of colon cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Multitargeted therapy of cancer by silymarin

1 reference

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IL-4-mediated drug resistance in colon cancer stem cells

1 reference

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Cancer stem cells: the lessons from pre-cancerous stem cells

1 reference

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Cancer stem cells: at the headwaters of tumor development

1 reference

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Cancer stem cells in solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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The theoretical basis of cancer-stem-cell-based therapeutics of cancer: can it be put into practice?

1 reference

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Identification of stem cells in small intestine and colon by marker gene Lgr5

1 reference

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Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis

1 reference

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The biology of cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Phenotypic characterization of human colorectal cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

1 reference

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Identification and expansion of human colon-cancer-initiating cells

1 reference

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Cancer stem cells: models and concepts

1 reference

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9 September 2017

Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia

1 reference

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A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).

1 reference

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9 September 2017

Wnt control of stem cells and differentiation in the intestinal epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Wnt signalling in stem cells and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

9 September 2017

Wnt, stem cells and cancer in the intestine

1 reference

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The stem cell niche: theme and variations

1 reference

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The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

1 reference

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Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Effect of silibinin in human colorectal cancer cells: targeting the activation of NF-κB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.

1 reference

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14 September 2017

Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

14 September 2017

Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer

1 reference

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Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

14 September 2017

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

14 September 2017

Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

14 September 2017

Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy

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The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

17 June 2018

Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

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Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

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Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: A mathematical approach.

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Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.

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Characterization of brain cancer stem cells: a mathematical approach.

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

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SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.

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21 August 2018

Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148115

21 August 2018

Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells

1 reference

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Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases

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21 August 2018

Colon cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24970802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/24970802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of NANOG and KLF4 for breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24970802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/24970802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.2068

0 references

1 reference

Europe PubMed Central

8 September 2017

1 reference

Europe PubMed Central

8 September 2017

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