The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells. (Q38987491)

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20 March 2020

title

The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells (English)

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Lei Jin

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Carleen Cullinane

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Grant McArthur

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Helen Rizos

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author name string

Branka Mijatov

2

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Dilini Gunatilake

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Jessamy C Tiffen

4

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Kavitha Gowrishankar

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Gulietta M Pupo

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Rab K Prinjha

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Nicholas Smithers

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Peter Hersey

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language of work or name

English

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publication date

6 June 2014

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Journal of Investigative Dermatology

20 March 2020

published in

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volume

134

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issue

11

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page(s)

2795-2805

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Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune.

20 March 2020

cites work

1 reference

12 December 2020

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

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Inhibition of BET bromodomain targets genetically diverse glioblastoma

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Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients

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RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells

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Histone deacetylases (HDACs) as mediators of resistance to apoptosis in melanoma and as targets for combination therapy with selective BRAF inhibitors.

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BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy

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Bim and Bmf in tissue homeostasis and malignant disease

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12 December 2020

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

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12 December 2020

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

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12 December 2020

Place your BETs: the therapeutic potential of bromodomains

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12 December 2020

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

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12 December 2020

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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12 December 2020

Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

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12 December 2020

Selective inhibition of BET bromodomains

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12 December 2020

Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.

1 reference

12 December 2020

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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12 December 2020

A landscape of driver mutations in melanoma

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12 December 2020

Suppression of inflammation by a synthetic histone mimic

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12 December 2020

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

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12 December 2020

Targeting epigenetic readers in cancer.

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12 December 2020

How melanoma cells evade trail-induced apoptosis.

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12 December 2020

Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma

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12 December 2020

The intersection of immune-directed and molecularly targeted therapy in advanced melanoma: where we have been, are, and will be.

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12 December 2020

Epigenetic protein families: a new frontier for drug discovery

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12 December 2020

Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells

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12 December 2020

Histone onco-modifications

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12 December 2020

Apoptosis in targeted therapy responses: the role of BIM.

1 reference

12 December 2020

Targeting MYC dependence in cancer by inhibiting BET bromodomains

1 reference

12 December 2020

Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

1 reference

12 December 2020

BET domain co-regulators in obesity, inflammation and cancer

1 reference

12 December 2020

Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors.

1 reference

12 December 2020

NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2

1 reference

12 December 2020

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

1 reference

12 December 2020

The BH3-only protein Bim(L) overrides Bcl-2-mediated apoptosis resistance in melanoma cells

1 reference

12 December 2020

Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies

1 reference

12 December 2020

Treatment of BRAF-mutant melanoma: the role of vemurafenib and other therapies

1 reference

12 December 2020

Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes.

1 reference

12 December 2020

Combination checkpoint blockade--taking melanoma immunotherapy to the next level.

1 reference

12 December 2020

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

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12 December 2020

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

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12 December 2020

Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness.

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12 December 2020

BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways

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12 December 2020

ChromHMM: automating chromatin-state discovery and characterization

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12 December 2020

Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria

1 reference

12 December 2020

Nuclear localization of the serine/threonine kinase DRAK2 is involved in UV-induced apoptosis

1 reference

12 December 2020

The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.

1 reference

12 December 2020

Cancer epigenetics: from mechanism to therapy

1 reference

12 December 2020

Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma

1 reference

12 December 2020

Epigenetic mechanisms in commonly occurring cancers.

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12 December 2020

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

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12 December 2020

Identifiers

DOI

10.1038/JID.2014.243

1 reference

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Dimensions Publication ID

20 March 2020

1036265002

0 references

1 reference

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