TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells. (Q39005258)

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13 March 2020

title

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells (English)

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human embryonic stem cell

13 March 2020

main subject

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12

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Nathalie Droin

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Thomas Mercher

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Francois Delhommeau

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Olivier Bernard

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Eric Solary

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William Vainchenker

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Isabelle Plo

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Nathalie Auger

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3

Gaëlle Lenglet

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Caroline Marty

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13

Najet Debili

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author name string

Thierry Langlois

1

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Barbara da Costa Reis Monte-Mor

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Jean-Pierre Le Couédic

6

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Carole Almire

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Jesper Christensen

11

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François Fuks

14

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language of work or name

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1 August 2014

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volume

32

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issue

8

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page(s)

2084-2097

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DNA methylation and chromatin - unraveling the tangled web.

13 March 2020

cites work

1 reference

Genetic and epigenetic regulators of pluripotency

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

21 January 2018

1 reference

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

1 reference

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

21 January 2018

1 reference

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

1 reference

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

21 January 2018

1 reference

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

21 January 2018

1 reference

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

1 reference

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

21 January 2018

1 reference

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

21 January 2018

1 reference

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

21 January 2018

1 reference

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

21 January 2018

1 reference

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

21 January 2018

1 reference

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

1 reference

Mutation in TET2 in myeloid cancers

21 January 2018

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TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia

21 January 2018

1 reference

Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

1 reference

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

21 January 2018

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

21 January 2018

1 reference

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

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Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

21 January 2018

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A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.

21 January 2018

1 reference

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

21 January 2018

1 reference

A mesoderm-derived precursor for mesenchymal stem and endothelial cells

21 January 2018

1 reference

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

21 January 2018

1 reference

Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency

21 January 2018

1 reference

Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures

21 January 2018

1 reference

Pluripotency factors regulate definitive endoderm specification through eomesodermin

21 January 2018

1 reference

FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation

21 January 2018

1 reference

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

21 January 2018

1 reference

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

21 January 2018

1 reference

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

21 January 2018

1 reference

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.

21 January 2018

1 reference

New cell lines from mouse epiblast share defining features with human embryonic stem cells

21 January 2018

1 reference

LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells

21 January 2018

1 reference

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

21 January 2018

1 reference

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/STEM.1718

1 reference

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13 March 2020

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