Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. (Q39013864)

PubMed publication ID

24647034

8 September 2017

title

Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270846&resulttype=core&format=json

13 May 2020

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6

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13 May 2020

author name string

Liang-Mou Kuo

1

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13 May 2020

Chan-Yen Kuo

2

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13 May 2020

Chen-Yu Lin

3

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13 May 2020

Min-Fa Hung

4

1 reference

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13 May 2020

Jiann-Jong Shen

5

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13 May 2020

language of work or name

English

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publication date

18 March 2014

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PubMed publication ID

8 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270846&resulttype=core&format=json

13 May 2020

volume

19

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13 May 2020

issue

3

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13 May 2020

page(s)

3327-3344

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Creative Commons Attribution 4.0 International

13 May 2020

copyright license

start time

18 March 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Hepatic stellate cells in liver development, regeneration, and cancer

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Pathogenesis of liver fibrosis

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Recent progress on anti-liver fibrosis candidates in patents of herbal medicinal products

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Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin

21 January 2018

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Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway

21 January 2018

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Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines

21 January 2018

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Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia

21 January 2018

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Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: studies in vitro and in vivo

21 January 2018

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Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.

21 January 2018

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Fibrosis-dependent mechanisms of hepatocarcinogenesis

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Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes

21 January 2018

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Glutathione and apoptosis

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Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death

21 January 2018

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Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways

21 January 2018

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Glutathione efflux and cell death

21 January 2018

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Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

21 January 2018

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Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis

21 January 2018

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Evolving therapies for liver fibrosis

21 January 2018

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Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice.

21 January 2018

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Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin

21 January 2018

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Hepatic stellate cells and liver fibrosis

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Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology.

21 January 2018

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Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death

21 January 2018

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Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells

21 January 2018

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Chronic vitamin C insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice

21 January 2018

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Cellular metabolic and autophagic pathways: traffic control by redox signaling

21 January 2018

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Mitogen-activated protein kinases in mammalian oxidative stress responses

21 January 2018

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Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway

21 January 2018

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Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress

21 January 2018

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Continuous presence of H2O2 induces mitochondrial-mediated, MAPK- and caspase-independent growth inhibition and cytotoxicity in human gingival fibroblasts

21 January 2018

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12 December 2020

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

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12 December 2020

Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin

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12 December 2020

Cellular basis of hepatic fibrosis and its role in inflammation and cancer

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12 December 2020

Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway

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12 December 2020

Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression

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12 December 2020

Hepatic stellate cells hold the key to liver fibrosis

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12 December 2020

Role of free radicals in liver diseases and hepatic fibrosis

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12 December 2020

An investigation of diterpenes from the leaves of Rabdosia trichocarpa and their antibacterial activity against oral microorganisms

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12 December 2020

Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis

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12 December 2020

10.3390/MOLECULES19033327

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270846&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270846&resulttype=core&format=json

13 May 2020

PubMed publication ID

24647034

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270846&resulttype=core&format=json