A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. (Q39022431)

8 September 2017

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. (English)

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8 September 2017

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7

Merone Roose-Girma

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8 September 2017

Aditya Murthy

1

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8 September 2017

Yun Li

2

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8 September 2017

Ivan Peng

3

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8 September 2017

Mike Reichelt

4

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8 September 2017

Anand Kumar Katakam

5

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8 September 2017

Rajkumar Noubade

6

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8 September 2017

Jason DeVoss

8

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8 September 2017

Lauri Diehl

9

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8 September 2017

Robert R Graham

10

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8 September 2017

Menno van Lookeren Campagne

11

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8 September 2017

language of work or name

English

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publication date

19 February 2014

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8 September 2017

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8 September 2017

506

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8 September 2017

456-462

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8 September 2017

7489

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https://scigraph.springernature.com/pub.10.1038/nature13044

8 September 2017

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cites work

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Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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12 December 2020

Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts

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12 December 2020

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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12 December 2020

XIAP discriminates between type I and type II FAS-induced apoptosis

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12 December 2020

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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12 December 2020

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant

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12 December 2020

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

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12 December 2020

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8.

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Bacterial subversion of host innate immune pathways

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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12 December 2020

Common alleles that influence autophagy and the risk for inflammatory bowel disease

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12 December 2020

Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

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Integrating common and rare genetic variation in diverse human populations

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid.

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Bringing genome-wide association findings into clinical use.

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

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A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

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12 December 2020

Simultaneous assessment of autophagy and apoptosis using multispectral imaging cytometry.

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12 December 2020

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

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12 December 2020

Metabolic stress in autophagy and cell death pathways

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12 December 2020

The Crohn's disease: associated ATG16L1 variant and Salmonella invasion

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12 December 2020

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Autophagy fights disease through cellular self-digestion

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Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

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The role of the immune system in governing host-microbe interactions in the intestine

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Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

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12 December 2020

Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

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12 December 2020

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

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12 December 2020

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

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12 December 2020

A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection

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12 December 2020

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

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A role for IL-1 alpha in inducing pathologic inflammation during bacterial infection

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12 December 2020

The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner

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12 December 2020

Yersinia enterocolitica induces apoptosis and inhibits surface molecule expression and cytokine production in murine dendritic cells

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12 December 2020

Inflammatory bowel disease

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12 December 2020

Identifiers

DOI

10.1038/NATURE13044

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Dimensions Publication ID

8 September 2017

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