Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease (Q22251069)

6 February 2023

60

Jack Satsangi

Jack

Satsangi

1 reference

6 February 2023

55

Rhian Gwilliam

Rhian

Gwilliam

1 reference

6 February 2023

62

Miles Parkes

Miles

Parkes

1 reference

6 February 2023

27

Mark Lathrop

Mark

Lathrop

1 reference

6 February 2023

34

Paul Rutgeerts

Paul

Rutgeerts

1 reference

6 February 2023

35

André Van Gossum

André

Van Gossum

1 reference

6 February 2023

39

Martine de Vos

Martine

de Vos

1 reference

6 February 2023

36

Diana Zelenika

Diana

Zelenika

1 reference

6 February 2023

29

Olivier Dewit

Olivier

Dewit

1 reference

6 February 2023

33

Myriam Mni

Myriam

Mni

1 reference

6 February 2023

26

Cynthia Sandor

Cynthia

Sandor

1 reference

6 February 2023

25

Cécile Libioulle

Cécile

Libioulle

1 reference

6 February 2023

52

Jonathan Marchini

Jonathan

Marchini

1 reference

6 February 2023

Richard H Duerr

5

Richard H

Duerr

1 reference

6 February 2023

Jeffrey C Barrett

1

Jeffrey C

Barrett

1 reference

6 February 2023

M Michael Barmada

10

M Michael

Barmada

1 reference

6 February 2023

Dan L Nicolae

3

Dan L

Nicolae

1 reference

6 February 2023

John D Rioux

6

John D

Rioux

1 reference

6 February 2023

19

Jerome I Rotter

Jerome I

Rotter

1 reference

6 February 2023

64

Mark J Daly

Mark J

Daly

1 reference

6 February 2023

Christopher G. Mathew

61

Christopher G Mathew

Christopher G

Mathew

1 reference

6 February 2023

9

Kent D Taylor

Kent D

Taylor

1 reference

6 February 2023

22

Stephan R Targan

Stephan R

Targan

1 reference

6 February 2023

23

Ramnik J Xavier

Ramnik J

Xavier

1 reference

6 February 2023

7

Steven R Brant

Steven R

Brant

1 reference

6 February 2023

8

Mark S Silverberg

Mark S

Silverberg

1 reference

6 February 2023

40

Severine Vermeire

Severine

Vermeire

1 reference

6 February 2023

4

Judy H Cho

Judy H

Cho

1 reference

6 February 2023

15

Anne M Griffiths

Anne M

Griffiths

1 reference

6 February 2023

41

Edouard Louis

Edouard

Louis

1 reference

6 February 2023

59

Derek Jewell

Derek

Jewell

1 reference

6 February 2023

21

A Hillary Steinhart

A Hillary

Steinhart

1 reference

6 February 2023

13

Lisa Wu Datta

Lisa Wu

Datta

1 reference

6 February 2023

18

Miguel D Regueiro

Miguel D

Regueiro

1 reference

6 February 2023

20

L Philip Schumm

L Philip

Schumm

1 reference

6 February 2023

45

Carl A Anderson

Carl A

Anderson

1 reference

6 February 2023

49

Natalie J Prescott

Natalie J

Prescott

1 reference

6 February 2023

Suzannah J. Bumpstead

54

Suzannah Bumpstead

Suzannah

Bumpstead

1 reference

6 February 2023

2

Sarah Hansoul

Sarah

Hansoul

1 reference

6 February 2023

11

Alain Bitton

Alain

Bitton

1 reference

6 February 2023

Emily Kistner-Griffin

16

Emily O Kistner

Emily O

Kistner

1 reference

6 February 2023

17

Michael T Murtha

Michael T

Murtha

1 reference

6 February 2023

28

Jacques Belaiche

Jacques

Belaiche

1 reference

6 February 2023

31

Simon Heath

Simon

Heath

1 reference

6 February 2023

32

Debby Laukens

Debby

Laukens

1 reference

6 February 2023

37

Denis Franchimont

Denis

Franchimont

1 reference

6 February 2023

46

Hazel Drummond

Hazel

Drummond

1 reference

6 February 2023

47

Elaine Nimmo

Elaine

Nimmo

1 reference

6 February 2023

50

Clive M Onnie

Clive M

Onnie

1 reference

6 February 2023

53

Jilur Ghori

Jilur

Ghori

1 reference

6 February 2023

Themistocles Dassopoulos

12

object named as

Themistocles Dassopoulos

Themistocles

Dassopoulos

1 reference

6 February 2023

51

Sheila A

Fisher

Sheila A Fisher

1 reference

6 February 2023

Todd Green

14

Todd

Green

1 reference

6 February 2023

Ivo Gut

30

Ivo

Gut

1 reference

6 February 2023

Jean-Pierre Hugot

38

Jean-Pierre

Hugot

1 reference

6 February 2023

Lon R Cardon

44

Lon R

Cardon

1 reference

6 February 2023

Tariq Ahmad

48

Tariq

Ahmad

1 reference

6 February 2023

Mark Tremelling

56

Mark

Tremelling

1 reference

6 February 2023

John Mansfield

58

John

Mansfield

1 reference

6 February 2023

Michel Georges

63

Michel

Georges

1 reference

6 February 2023

the NIDDK IBD Genetics Consortium

24

0 references

the Belgian-French IBD Consortium

42

0 references

the Wellcome Trust Case Control Consortium

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

43

0 references

language of work or name

English

0 references

publication date

29 June 2008

0 references

August 2008

0 references

published in

Nature Genetics

0 references

volume

40

0 references

page(s)

955-962

0 references

955-62

0 references

issue

8

0 references

cites work

1 reference

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

PLINK: a tool set for whole-genome association and population-based linkage analyses

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Intelectin: a novel lipid raft-associated protein in the enterocyte brush border

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Functional variants of OCTN cation transporter genes are associated with Crohn disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

7 April 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038/NG.175

A new multipoint method for genome-wide association studies by imputation of genotypes

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A genome-wide association study of global gene expression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Phenotypic and functional features of human Th17 cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Population structure, differential bias and genomic control in a large-scale, case-control association study

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Interleukin-18 and the pathogenesis of inflammatory diseases

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574810

Integrating case-control and TDT studies

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18587394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18587394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.175

1 reference

661027

0 references

661027

1 reference

1 reference

1 reference