Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. (Q39034736)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Adrian S. Ray

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

26

Aesop Cho

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

6

Martijn Fenaux

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1

Joy Y Feng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

23

Weidong Zhong

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

3

Jason Perry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

4

Ona Barauskas

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

8

Neeraj Tirunagari

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

7

Stacey Eng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Guofeng Cheng

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Yili Xu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Betty Peng

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Mei Yu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Yang Tian

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Yu-Jen Lee

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

George Stepan

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Leanna L Lagpacan

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Debi Jin

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Magdeleine Hung

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Karin S Ku

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Bin Han

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Kathryn Kitrinos

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Michel Perron

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Kelly A Wong

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Choung U Kim

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Anne Carey

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

13 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

number of pages

13

1 reference

Antimicrobial Agents and Chemotherapy

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

1930-1942

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 March 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4023746/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Nucleotide prodrugs for HCV therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Turning hepatitis C into a real virus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

HCV NS5B polymerase inhibitors.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Diagnosis, management, and treatment of hepatitis C: an update

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

euHCVdb: the European hepatitis C virus database

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Mitochondrial toxicity and HIV therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Development of robust hepatitis C virus genotype 4 subgenomic replicons

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A-H and its use in antiviral phenotyping assays

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Biochemical characterization of rhinovirus RNA-dependent RNA polymerase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023746

Affinity labeling and measurement of DNA-induced conformation change in RNA polymerase II

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24419349

12 December 2020

inferred from PubMed ID database lookup

Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24419349

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/AAC.02351-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24419349%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference