BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1. (Q39036236)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1 (English)

1 reference

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4 March 2020

2

1 reference

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4 March 2020

author name string

Helen Jayne Susan Stewart

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Sarah Bastow

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Timothy James Telfer Chevassut

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

language of work or name

English

0 references

publication date

31 October 2013

1 reference

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4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

issue

6

1 reference

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4 March 2020

page(s)

826-835

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting

4 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Histone recognition and large-scale structural analysis of the human bromodomain family

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Targeting MYC dependence in cancer by inhibiting BET bromodomains

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

The impact of acetylation and deacetylation on the p53 pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

9 September 2017

1 reference

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Suppression of inflammation by a synthetic histone mimic

9 September 2017

1 reference

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New insights into p53 activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

BRD7 is a candidate tumour suppressor gene required for p53 function

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

H2AX is required for cell cycle arrest via the p53/p21 pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Acetylation is indispensable for p53 activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Chromatin modifications and their function

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Signaling pathways activated by daunorubicin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

9 September 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

The polo-like kinase inhibitor BI 2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiple myeloma

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Abnormalities of the P53, MDM2, BCL2 and BAX genes in acute leukemias.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3892387

Low frequency of DNMT3A mutations in pediatric AML and the identification of the OCI-AML3 cell line as an in vitro model

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCAM4.146

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCAM4.146

The NPM1 wild-type OCI-AML2 and the NPM1-mutated OCI-AML3 cell lines carry DNMT3A mutations

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24403256

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24403256

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24403256

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CAM4.146

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24403256%20AND%20SRC:MED&resulttype=core&format=json