Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation (Q35089377)

6 August 2017

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title

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation (English)

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6 August 2017

protein ubiquitination

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1 reference

Christopher L Brooks

1

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PubMed ID

12648672

6 August 2017

Wei Gu

series ordinal

2

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6 August 2017

1 April 2003

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Current Opinion in Cell Biology

6 August 2017

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6 August 2017

15

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6 August 2017

164-171

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6 August 2017

2

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p53, the cellular gatekeeper for growth and division

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Surfing the p53 network

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Regulation and function of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Stress signals utilize multiple pathways to stabilize p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Cyclin G recruits PP2A to dephosphorylate Mdm2

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

1 reference

7 January 2021

Molecular biology. Getting p53 out of the nucleus.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The p53 and Mdm2 families in cancer.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The ins and outs of p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

ARF function does not require p53 stabilization or Mdm2 relocalization

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Excess beta-catenin promotes accumulation of transcriptionally active p53.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

JNK targets p53 ubiquitination and degradation in nonstressed cells

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

NQO1 stabilizes p53 through a distinct pathway

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

ASPP proteins specifically stimulate the apoptotic function of p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Acetylation: a regulatory modification to rival phosphorylation?

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Synergistic activation of transcription by CBP and p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Acetylation of histones and transcription-related factors

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Regulation of the specific DNA binding function of p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

High mobility group protein-1 (HMG-1) is a unique activator of p53

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Human Sir2 and the 'silencing' of p53 activity

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Deacetylation of p53 modulates its effect on cell growth and apoptosis

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Histone deacetylases specifically down-regulate p53-dependent gene activation

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Atmospheric carbon dioxide concentrations over the past 60 million years

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

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https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

Acetylation of p53 inhibits its ubiquitination by Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2803%2900003-6

7 January 2021

10.1016/S0955-0674(03)00003-6

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12648672