Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway (Q39047641)

8 September 2017

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway (English)

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8 September 2017

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Edward W Harhaj

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8 September 2017

Nicole S Harhaj

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8 September 2017

Christian Grant

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8 September 2017

Kate Mostoller

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Timothy Alefantis

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8 September 2017

Shao-Cong Sun

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8 September 2017

Brian Wigdahl

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8 September 2017

language of work or name

English

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publication date

1 March 2005

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333

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145-158

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Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis

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CD40 ligand is a T cell growth factor

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The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

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HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

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I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

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CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes

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A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory

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Activation of human dendritic cells through CD40 cross-linking.

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

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IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.

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Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

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Immune regulation by CD40 and its ligand GP39.

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Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

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Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

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IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein

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Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation.

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Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein

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A novel function of CD40: induction of cell death in transformed cells

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Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I.

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

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Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

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Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10

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Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

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Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation.

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Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages

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Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages

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HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

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CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB

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Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I.

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HTLV-I associated myelopathy, a new clinical entity.

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The HTLV-I tax protein transcriptionally modulates OX40 antigen expression

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A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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inferred from DOI database lookup

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based on heuristic

Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B.

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inferred from DOI database lookup

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based on heuristic

Identifiers

DOI

10.1016/J.VIROL.2004.12.008

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8 September 2017

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