SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma (Q39069350)

8 September 2017

title

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma (English)

1 reference

8 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

E Sievers

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Aretz

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

D Kindler

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Michels

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

N Friedrichs

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

M Renner

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

J Kirfel

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Steiner

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Huss

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

A Koch

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

R Penzel

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

O Larsson

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

A Kawai

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Tanaka

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

H Sonobe

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

A Waha

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

P Schirmacher

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

G Mechtersheimer

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

E Wardelmann

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

R Büttner

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

W Hartmann

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

28 October 2013

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

5006-5016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma

3 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Synovial sarcoma: from genetics to genetic-based animal modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Molecular characterisation of soft tissue tumours: a gene expression study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Classification and subtype prediction of adult soft tissue sarcoma by functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Gene expression profiling of human sarcomas: insights into sarcoma biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Mining the Wnt pathway for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Wnt/β-catenin signaling and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Wnt signalling and its impact on development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

WNT signalling pathways as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

CK1epsilon is required for breast cancers dependent on beta-catenin activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

A conditional mouse model of synovial sarcoma: insights into a myogenic origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

SRC signaling is crucial in the growth of synovial sarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Synergism of heat shock protein 90 and histone deacetylase inhibitors in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Translocation X;18 in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

SSX and the synovial-sarcoma-specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

The synovial-sarcoma-associated SS18-SSX2 fusion protein induces epigenetic gene (de)regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

APC mutations in synovial sarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Nuclear beta-catenin in mesenchymal tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Expression of cadherins and their undercoat proteins (alpha-, beta-, and gamma-catenins and p120) and accumulation of beta-catenin with no gene mutations in synovial sarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

Pitfalls in the detection of t(11;22) translocation by fluorescence in situ hybridization and RT-PCR: a single-blinded study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.443

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.443

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24166495%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference