Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. (Q39069500)

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28 February 2020

title

Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo (English)

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Wen-Zhong Du

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Chuan-Lu Jiang

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publication date

25 October 2013

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CNS Neuroscience & Therapeutics

28 February 2020

published in

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volume

19

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issue

12

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page(s)

926-936

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

28 February 2020

cites work

1 reference

Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

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Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

21 January 2018

1 reference

Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway

21 January 2018

1 reference

The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma

21 January 2018

1 reference

Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway

21 January 2018

1 reference

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy.

21 January 2018

1 reference

Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells.

21 January 2018

1 reference

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

21 January 2018

1 reference

Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway

21 January 2018

1 reference

Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines

21 January 2018

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Expression of bcl-2, bax and bcl-xl in human gliomas: a re-appraisal.

21 January 2018

1 reference

FoxM1: a potential drug target for glioma

21 January 2018

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A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).

21 January 2018

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Adult glioblastoma multiforme survival in the temozolomide era: a population-based analysis of Surveillance, Epidemiology, and End Results registries

21 January 2018

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Sonic Hedgehog/GLI₁ signaling pathway inhibition restricts cell migration and invasion in human gliomas

21 January 2018

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Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells.

21 January 2018

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

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Curcumin: the Indian solid gold

21 January 2018

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Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells

21 January 2018

1 reference

Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.

21 January 2018

1 reference

Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo

21 January 2018

1 reference

Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein

21 January 2018

1 reference

The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.

21 January 2018

1 reference

Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways

21 January 2018

1 reference

Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors.

21 January 2018

1 reference

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

21 January 2018

1 reference

Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

21 January 2018

1 reference

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

21 January 2018

1 reference

Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy

21 January 2018

1 reference

p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression

21 January 2018

1 reference

Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells

21 January 2018

1 reference

Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells.

21 January 2018

1 reference

Curcumin blocks brain tumor formation

21 January 2018

1 reference

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

21 January 2018

1 reference

12 December 2020

FOXM1 is a downstream target of Gli1 in basal cell carcinomas

1 reference

12 December 2020

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts

1 reference

12 December 2020

miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.

1 reference

12 December 2020

LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12163

1 reference

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28 February 2020

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