Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment (Q39069971)

8 September 2017

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment (English)

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8 September 2017

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8 September 2017

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8 September 2017

Mariantonietta Capristo

Mariantonietta Capristo

3

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Valentina Giorgio

Valentina Giorgio

5

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Ivana Kurelac

Ivana Kurelac

2

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Luisa Iommarini

Luisa Iommarini

1

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Michela Rugolo

Michela Rugolo

13

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Valerio Carelli

Valerio Carelli

10

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Carla De Giovanni

9

Carla De Giovanni

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8 September 2017

7

Anna Ghelli

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8 September 2017

15

Anna Maria Porcelli

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8 September 2017

Maria Antonietta Calvaruso

4

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8 September 2017

Christian Bergamini

6

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8 September 2017

Romana Fato

11

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8 September 2017

Giuseppe Gasparre

14

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8 September 2017

24 October 2013

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8 September 2017

Human Molecular Genetics

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8 September 2017

23

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8 September 2017

1453-1466

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8 September 2017

6

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Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond.

8 September 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Human mitochondrial DNA: roles of inherited and somatic mutations

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Genetic insights into OXPHOS defect and its role in cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The role of mitochondria in the pathogenesis of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

21 January 2018

Mitochondria and cancer

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Complex I impairment in mitochondrial diseases and cancer: parallel roads leading to different outcomes

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Relevance of mitochondrial genetics and metabolism in cancer development

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Hypoxia-inducible factors and the response to hypoxic stress

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

AMP-activated protein kinase: the energy charge hypothesis revisited

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Universal heteroplasmy of human mitochondrial DNA.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

mtDNA mutations increase tumorigenicity in prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Spectrum of somatic mitochondrial mutations in five cancers

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Homoplasmic MELAS A3243G mtDNA mutation in a colon cancer sample.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Bioenergetics of mitochondrial diseases associated with mtDNA mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The effects of idebenone on mitochondrial bioenergetics

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

NIH Image to ImageJ: 25 years of image analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

Platelet transfusion can mimic somatic mtDNA mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT533

21 January 2018

Identifiers

DOI

10.1093/HMG/DDT533

1 reference

8 September 2017

1 reference