The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. (Q34762767)

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2 March 2020

title

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling (English)

1 reference

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2 March 2020

1 reference

1

1 reference

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2 March 2020

Eric Dufour

5

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2 March 2020

8

Ralph J Deberardinis

1 reference

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2 March 2020

author name string

Eva Martinez-Garcia

2

1 reference

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2 March 2020

Hien Nguyen

3

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2 March 2020

Andrew R Mullen

4

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2 March 2020

Sunil Sudarshan

6

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2 March 2020

Jonathan D Licht

7

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2 March 2020

Navdeep S Chandel

9

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2 March 2020

publication date

6 June 2013

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2 March 2020

1 reference

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2 March 2020

volume

51

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2 March 2020

issue

2

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2 March 2020

page(s)

236-248

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

2 March 2020

cites work

1 reference

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

7 July 2018

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Hypoxia-inducible factors in physiology and medicine

7 July 2018

1 reference

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

7 July 2018

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

7 July 2018

1 reference

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An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

7 July 2018

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Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

7 July 2018

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The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

7 July 2018

1 reference

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Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

7 July 2018

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

7 July 2018

1 reference

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Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion

7 July 2018

1 reference

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

7 July 2018

1 reference

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Mitochondria-targeted small molecule therapeutics and probes

7 July 2018

1 reference

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Regulation of cancer cell metabolism

7 July 2018

1 reference

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

7 July 2018

1 reference

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Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

7 July 2018

1 reference

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

7 July 2018

1 reference

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Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3775267

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

7 July 2018

1 reference

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

7 July 2018

1 reference

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Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin

7 July 2018

1 reference

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

7 July 2018

1 reference

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

7 July 2018

1 reference

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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

7 July 2018

1 reference

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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

7 July 2018

1 reference

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Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress

7 July 2018

1 reference

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

7 July 2018

1 reference

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

7 July 2018

1 reference

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Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters.

7 July 2018

1 reference

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

7 July 2018

1 reference

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On the Origin of Cancer Cells

7 July 2018

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

7 July 2018

1 reference

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

7 July 2018

1 reference

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Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

7 July 2018

1 reference

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A simple spectrophotometric assay for fumarate hydratase in crude tissue extracts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3775267

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

7 July 2018

1 reference

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3775267

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23747014

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23747014

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2013.05.003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23747014%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23747014%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23747014%20AND%20SRC:MED&resulttype=core&format=json