Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). (Q39093865)

9 September 2017

Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). (English)

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9 September 2017

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Rithwik Ramachandran

2

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author name string

Koichiro Mihara

1

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9 September 2017

Bernard Renaux

3

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9 September 2017

Mahmoud Saifeddine

4

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9 September 2017

Morley D Hollenberg

5

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9 September 2017

language of work or name

English

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publication date

19 September 2013

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Journal of Biological Chemistry

9 September 2017

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9 September 2017

288

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9 September 2017

32979-32990

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9 September 2017

46

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describes a project that uses

9 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3829148/fullTextXML

inferred from PubMed Central ID database lookup

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Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.

9 September 2017

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9 September 2017

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Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds

9 September 2017

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A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

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Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)

9 September 2017

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Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis

9 September 2017

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Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

9 September 2017

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Caveolae are required for protease-selective signaling by protease-activated receptor-1.

9 September 2017

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Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis

9 September 2017

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9 September 2017

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Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

9 September 2017

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Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

9 September 2017

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The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

9 September 2017

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Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

9 September 2017

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Proteinase-activated receptors, targets for kallikrein signaling

9 September 2017

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Neutrophil serine proteases: specific regulators of inflammation

9 September 2017

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

9 September 2017

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Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

9 September 2017

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A dual thrombin receptor system for platelet activation

9 September 2017

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Cloning and characterization of human protease-activated receptor 4

9 September 2017

1 reference

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Molecular cloning of a potential proteinase activated receptor

9 September 2017

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The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression

9 September 2017

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Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

9 September 2017

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Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

9 September 2017

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

9 September 2017

1 reference

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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

9 September 2017

1 reference

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Proteinase-activated receptor 2: differential activation of the receptor by tethered ligand and soluble peptide analogs

14 September 2017

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Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site

25 September 2017

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Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3.

15 June 2018

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Domains specifying thrombin–receptor interaction

15 June 2018

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β-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells.

15 June 2018

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Functional selectivity and biased receptor signaling.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829148

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis

21 August 2018

1 reference

12 December 2020

Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1

1 reference

12 December 2020

Cyclic AMP-elevating agents induce the expression of MAP kinase phosphatase-1 in PC12 cells

1 reference

12 December 2020

Covalent binding of human thrombin to a human endothelial cell-associated protein

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12 December 2020

Identifiers

DOI

10.1074/JBC.M113.483123

1 reference

9 September 2017

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9 September 2017

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