Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway (Q39101720)

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scientific article published on 31 August 2013

Language	Label	Description	Also known as
English	Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway	scientific article published on 31 August 2013

Statements

scholarly article

1 reference

Europe PubMed Central

9 September 2017

Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway (English)

1 reference

Europe PubMed Central

9 September 2017

Piero Marchetti

11

1 reference

Europe PubMed Central

9 September 2017

Annalisa Natalicchio

object named as

Annalisa Natalicchio

1

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object named as

Luigi Laviola

13

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Angelo Cignarelli

object named as

Angelo Cignarelli

10

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Sebastio Perrini

object named as

Sebastio Perrini

12

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Francesco Giorgino

object named as

Francesco Giorgino

14

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Giuseppina Biondi

object named as

Giuseppina Biondi

4

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object named as

Nicola Marrano

5

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Alessandro Peschechera

6

object named as

Alessandro Peschechera

1 reference

Europe PubMed Central

9 September 2017

Maura Roberta Orlando

8

object named as

Maura Roberta Orlando

1 reference

Europe PubMed Central

9 September 2017

Anna Leonardini

9

object named as

Anna Leonardini

1 reference

Europe PubMed Central

9 September 2017

Federica Tortosa

3

object named as

Federica Tortosa

1 reference

Europe PubMed Central

9 September 2017

Rossella Labarbuta

2

object named as

Rossella Labarbuta

1 reference

Europe PubMed Central

9 September 2017

Emanuele Carchia

7

object named as

Emanuele Carchia

1 reference

Europe PubMed Central

9 September 2017

publication date

31 August 2013

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

56

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Europe PubMed Central

9 September 2017

11

1 reference

Europe PubMed Central

9 September 2017

2456-2466

1 reference

Europe PubMed Central

9 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-013-3028-4

0 references

An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Management of type 2 diabetes: new and future developments in treatment

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

The incretin hormones: from scientific discovery to practical therapeutics.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Incretin effects on β-cell function, replication, and mass: the human perspective

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Autophagy in human type 2 diabetes pancreatic beta cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

siRNA produced by recombinant dicer mediates efficient gene silencing in islet cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Fatty acid metabolism and insulin secretion in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Physiological roles of MKK4 and MKK7: insights from animal models

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Metabolic stress signaling mediated by mixed-lineage kinases

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Cell death-inducing DFF45-like effector b (Cideb) is present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

The role of GLP-1 in the regulation of islet cell mass.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-013-3028-4

21 January 2018

Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protocol for islet isolation from mouse pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the insulin gene by glucose and fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-013-3028-4

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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