Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). (Q33184955)

23 July 2017

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). (English)

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23 July 2017

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Christian E Wrede

1

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23 July 2017

Lorna M Dickson

2

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23 July 2017

Melissa K Lingohr

3

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23 July 2017

Isabelle Briaud

4

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23 July 2017

Christopher J Rhodes

5

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23 July 2017

language of work or name

English

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publication date

21 October 2002

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Journal of Biological Chemistry

23 July 2017

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23 July 2017

277

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23 July 2017

49676-49684

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23 July 2017

51

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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

23 July 2017

1 reference

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Diseases of liporegulation: new perspective on obesity and related disorders

21 January 2018

1 reference

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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

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Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

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beta-cell turnover: its assessment and implications

21 January 2018

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 January 2018

1 reference

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Molecular insights into insulin action and secretion

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208756200

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

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A signaling pathway to translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

21 January 2018

1 reference

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21 January 2018

Caspases: enemies within

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Cell cycle and death control: long live Forkheads

21 January 2018

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Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.

21 January 2018

1 reference

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The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

21 January 2018

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The p53 pathway and apoptosis

21 January 2018

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p53 function and dysfunction

21 January 2018

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Signal transduction of stress via ceramide

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208756200

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208756200

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208756200

Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia

21 January 2018

1 reference

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New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

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Cellular mechanisms of insulin resistance

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M208756200

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23 July 2017

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