Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock (Q39103864)

7 June 2018

title

Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock (English)

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7 June 2018

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author name string

Murielle Grégoire

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7 June 2018

Jean-Marc Tadié

2

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7 June 2018

Arnaud Gacouin

4

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7 June 2018

Caroline Piau

5

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7 June 2018

Nathaniel Bone

6

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7 June 2018

Yves Le Tulzo

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7 June 2018

Edward Abraham

8

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7 June 2018

Karin Tarte

9

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Jaroslaw W Zmijewski

10

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7 June 2018

publication date

13 December 2016

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7 June 2018

Journal of Leukocyte Biology

published in

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7 June 2018

volume

101

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7 June 2018

page(s)

1281-1287

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7 June 2018

issue

6

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7 June 2018

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia

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PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

17 June 2018

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Persistent neutrophil dysfunction and suppression of acute lung injury in mice following cecal ligation and puncture sepsis

17 June 2018

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An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor

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17 June 2018

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Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis

17 June 2018

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Sepsis definitions: time for change

17 June 2018

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The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

17 June 2018

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Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

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Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism

17 June 2018

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Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis.

17 June 2018

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Immunosuppression in patients who die of sepsis and multiple organ failure

17 June 2018

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Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing

17 June 2018

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The late phase of sepsis is characterized by an increased microbiological burden and death rate

17 June 2018

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HMGB1 is a therapeutic target for sterile inflammation and infection

17 June 2018

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Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma

17 June 2018

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Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase

17 June 2018

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HMGB1 and RAGE in inflammation and cancer

17 June 2018

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The sepsis seesaw: tilting toward immunosuppression

17 June 2018

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17 June 2018

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Novel HMGB1-inhibiting therapeutic agents for experimental sepsis

17 June 2018

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Immunodesign of experimental sepsis by cecal ligation and puncture

17 June 2018

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17 June 2018

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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

17 June 2018

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How neutrophils kill microbes

17 June 2018

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Activation and assembly of the NADPH oxidase: a structural perspective

17 June 2018

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The chronic consequences of severe sepsis

17 June 2018

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Chronic granulomatous disease: more than the lack of superoxide?

17 June 2018

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17 June 2018

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Generation of nitric oxide and reactive oxygen species by neutrophils and monocytes from septic patients and association with outcomes.

21 August 2018

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Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5433854

Reactivity of 2',7'-dichlorodihydrofluorescein and dihydrorhodamine 123 and their oxidized forms toward carbonate, nitrogen dioxide, and hydroxyl radicals

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5433854

Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5433854

The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5433854

Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

21 August 2018

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12 December 2020

Immunosuppression in sepsis

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12 December 2020

HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis

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12 December 2020

Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients

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12 December 2020

Sepsis studies need new direction

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12 December 2020

Prediction of nosocomial infection acquisition in ventilated patients by nasal nitric oxide: proof-of-concept study

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12 December 2020

High-mobility group box 1 protein plasma concentrations during septic shock

1 reference

12 December 2020

10.1189/JLB.5HI0316-128RR

Identifiers

DOI

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7 June 2018

PMCID

5433854

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7 June 2018

PubMed ID

27965385

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7 June 2018