PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis (Q33926167)

30 July 2017

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis (English)

1 reference

30 July 2017

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Haichao Wang

10

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Timothy Billiar

9

object named as

Timothy R Billiar

1 reference

30 July 2017

8

Michael T Lotze

1 reference

30 July 2017

Liangchun Yang

1

1 reference

30 July 2017

Min Xie

2

1 reference

30 July 2017

Minghua Yang

3

1 reference

30 July 2017

Yan Yu

4

1 reference

30 July 2017

Shan Zhu

5

1 reference

30 July 2017

Wen Hou

6

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30 July 2017

Rui Kang

7

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30 July 2017

Lizhi Cao

11

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30 July 2017

Daolin Tang

12

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30 July 2017

language of work or name

English

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publication date

14 July 2014

1 reference

30 July 2017

Nature Communications

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30 July 2017

5

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30 July 2017

4436

1 reference

https://scigraph.springernature.com/pub.10.1038/ncomms5436

30 July 2017

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cites work

Pharmacological properties of shikonin - a review of literature since 2002.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Severe sepsis and septic shock

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Metabolism of inflammation limited by AMPK and pseudo-starvation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Prognostic significance of blood lactate and lactate clearance in trauma patients

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

The high mobility group box: the ultimate utility player of a cell.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Metabolic checkpoints in activated T cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Emerging roles of PKM2 in cell metabolism and cancer progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Orchestration of metabolism by macrophages

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Regulation of metabolism by hypoxia-inducible factor 1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

High-mobility group box 1 is essential for mitochondrial quality control

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Targeting Hypoxia-induced Inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

HMGB1 is a therapeutic target for sterile inflammation and infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Endogenous HMGB1 regulates autophagy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Cancer cell metabolism: Warburg and beyond

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Serum lactate as a predictor of mortality in emergency department patients with infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

HIF-1alpha is essential for myeloid cell-mediated inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

The many faces of macrophage activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

HMGB1 as a late mediator of lethal systemic inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

HMG-1 as a late mediator of endotoxin lethality in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

International study of the prevalence and outcomes of infection in intensive care units

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Hypoxia and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-γ and TNF-α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5436

Bone Marrow-Derived Macrophages (BMM): Isolation and Applications

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104986

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25019241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25019241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25019241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS5436

1 reference

Dimensions Publication ID

30 July 2017

0 references

0 references

1 reference

30 July 2017

1 reference