Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis (Q39109576)

9 September 2017

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis (English)

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9 September 2017

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9

Brian R Wamhoff

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9 September 2017

2

Banumathi K Cole

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9 September 2017

6

Brett R Blackman

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9 September 2017

Ryan E Feaver

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9 September 2017

Mark J Lawson

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9 September 2017

Stephen A Hoang

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9 September 2017

Svetlana Marukian

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9 September 2017

Robert A Figler

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9 September 2017

Arun J Sanyal

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9 September 2017

Ajit Dash

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9 September 2017

8 December 2016

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9 September 2017

e90954

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describes a project that uses

9 September 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5135271

inferred from PubMed Central ID database lookup

cites work

Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease

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Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

9 September 2017

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Near-optimal probabilistic RNA-seq quantification

9 September 2017

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Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

9 September 2017

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Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting.

9 September 2017

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Inflammasomes: mechanism of action, role in disease, and therapeutics

9 September 2017

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Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

9 September 2017

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Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.

9 September 2017

1 reference

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YKL-40 is a Protective Biomarker for Fatty Liver in World Trade Center Particulate Matter-Exposed Firefighters

9 September 2017

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Microengineered liver tissues for drug testing

9 September 2017

1 reference

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limma powers differential expression analyses for RNA-sequencing and microarray studies

9 September 2017

1 reference

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Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

9 September 2017

1 reference

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Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

9 September 2017

1 reference

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

ForceAtlas2, a continuous graph layout algorithm for handy network visualization designed for the Gephi software.

9 September 2017

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The Reactome pathway knowledgebase

9 September 2017

1 reference

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Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

From fatty liver to fibrosis: a tale of "second hit".

9 September 2017

1 reference

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Pathophysiology of NASH: perspectives for a targeted treatment

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Organotypic liver culture models: meeting current challenges in toxicity testing

9 September 2017

1 reference

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Protective and pathogenic functions of macrophage subsets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

ROAST: rotation gene set tests for complex microarray experiments

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Non alcoholic fatty liver disease and metabolic syndrome.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

arrayQualityMetrics--a bioconductor package for quality assessment of microarray data

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

A novel signaling pathway impact analysis.

9 September 2017

1 reference

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STRING 8--a global view on proteins and their functional interactions in 630 organisms

9 September 2017

1 reference

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PID: the Pathway Interaction Database

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Capturing heterogeneity in gene expression studies by surrogate variable analysis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Nonalcoholic fatty liver disease: a clinical review

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Initial sequencing and analysis of the human genome

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Gene ontology: tool for the unification of biology

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

KEGG: kyoto encyclopedia of genes and genomes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

A liver-on-a-chip platform with bioprinted hepatic spheroids.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Adipophilin/perilipin-2 as a lipid droplet-specific marker for metabolically active cells and diseases associated with metabolic dysregulation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

A lipidomic analysis of nonalcoholic fatty liver disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

Drug-induced steatohepatitis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135271

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

21 August 2018

1 reference

12 December 2020

Serum YKL-40 is increased in patients with hepatic fibrosis

1 reference

12 December 2020

Liver fibrosis: the hepatocyte revisited

1 reference

12 December 2020

In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

1 reference

12 December 2020

Serum YKL-40 concentrations in patients with early rheumatoid arthritis: relation to joint destruction

1 reference

12 December 2020

10.1172/JCI.INSIGHT.90954

Identifiers

DOI

0 references

1 reference

9 September 2017

PubMed publication ID

27942596

1 reference