Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability (Q39113007)

9 September 2017

Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability (English)

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9 September 2017

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9 September 2017

Brendan T Griffin

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author name string

Fionn E O'Brien

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1

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9 September 2017

9 August 2013

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The International Journal of Neuropsychopharmacology

9 September 2017

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9 September 2017

16

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9 September 2017

10

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9 September 2017

2259-2272

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Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series

9 September 2017

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Integration of in silico and in vitro tools for scaffold optimization during drug discovery: predicting P-glycoprotein efflux

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

MDR1 gene polymorphism: therapeutic response to paroxetine among patients with major depression

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Changes in the brain accumulation of glucocorticoids in abcb1a-deficient CF-1 mice

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Scientific perspectives on drug transporters and their role in drug interactions

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Several major antiepileptic drugs are substrates for human P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

In vitro trans-monolayer permeability calculations: often forgotten assumptions

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Inhibition of P-glycoprotein by newer antidepressants

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

ABC multidrug transporters: structure, function and role in chemoresistance.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Diagnosis and definition of treatment-resistant depression

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1461145713000692

In vitro and in vivo evaluation of the effects of duloxetine on P-gp function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

Altered brain concentrations of citalopram and escitalopram in P-glycoprotein deficient mice after acute and chronic treatment.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

ABCB1 (P-glycoprotein/MDR1) gene G2677T/a sequence variation (polymorphism): lack of association with side effects and therapeutic response in depressed inpatients treated with amitriptyline

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

Drug resistance in brain diseases and the role of drug efflux transporters.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents

1 reference

https://api.crossref.org/works/10.1017%2FS1461145713000692

7 January 2021

10.1017/S1461145713000692

Identifiers

DOI

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9 September 2017

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PubMed ID

23931269