Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells (Q39120190)

9 September 2017

Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells (English)

1 reference

9 September 2017

1 reference

1 reference

Cindy R Timme

1

1 reference

PubMed ID

23887890

9 September 2017

Mike Gruidl

series ordinal

2

1 reference

PubMed ID

23887890

9 September 2017

Timothy J Yeatman

series ordinal

3

1 reference

9 September 2017

1 October 2013

1 reference

9 September 2017

1 reference

9 September 2017

18

1 reference

9 September 2017

10

1 reference

9 September 2017

1163-1174

1 reference

https://scigraph.springernature.com/pub.10.1007/s10495-013-0883-x

9 September 2017

0 references

cites work

Cancer statistics, 2012

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Progress in metastatic colorectal cancer: growing role of cetuximab to optimize clinical outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

The Notch signaling pathway: transcriptional regulation at Notch target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Aberrant activation of notch signaling in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch1 is an effector of Akt and hypoxia in melanoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch1 expression correlates with tumor differentiation status in ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Recent insights into the role of Notch signaling in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Expression of notch receptors and ligands in the adult gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Self-renewal and cancer of the gut: two sides of a coin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Control of mitochondrial apoptosis by the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

A phase II study of RO4929097 in metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Notch signals control the fate of immature progenitor cells in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0883-X

Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways

21 January 2018

1 reference

3 January 2024

https://opencitations.net/index/api/v1/citations/10.1002/JCB.22451

Identifiers

DOI

10.1007/S10495-013-0883-X

1 reference

9 September 2017

1 reference

PubMed ID

23887890