Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities (Q28588005)

31 January 2017

title

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities (English)

1 reference

Aph1 homolog A, gamma secretase subunit

31 January 2017

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Presenilin 1

1 reference

GOA release 2020-03-11

11

Charles G. Eberhart

1 reference

31 January 2017

Tong Li

1

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Hongjin Wen

2

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Cory Brayton

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Guojun Ma

5

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Shiwen Peng

6

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Lisa Placanica

7

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Fiona M Laird

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

T C Wu

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Barbara J Crain

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Donald L Price

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Charles G Eberhart

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

Philip C Wong

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

language of work or name

English

0 references

publication date

3 October 2007

1 reference

31 January 2017

published in

Journal of Neuroscience

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

volume

27

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

issue

40

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

page(s)

10849-10859

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

describes a project that uses

16 May 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6672827/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Notch signaling: cell fate control and signal integration in development

1 reference

12 December 2020

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

12 December 2020

Evaluating mutant mice: anatomic pathology

1 reference

12 December 2020

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

12 December 2020

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.

1 reference

12 December 2020

beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology

1 reference

12 December 2020

An invitation to T and more: notch signaling in lymphopoiesis

1 reference

12 December 2020

Gastrointestinal stem cells

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis

1 reference

12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

12 December 2020

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

12 December 2020

Notch1 functions as a tumor suppressor in mouse skin

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

12 December 2020

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

1 reference

12 December 2020

Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease

1 reference

12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

12 December 2020

Multiple niches for Notch in cancer: context is everything

1 reference

12 December 2020

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

1 reference

12 December 2020

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

1 reference

12 December 2020

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

1 reference

12 December 2020

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

1 reference

12 December 2020

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

1 reference

12 December 2020

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

12 December 2020

Alzheimer disease and cancer

1 reference

12 December 2020

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

1 reference

12 December 2020

DJ-1, a novel regulator of the tumor suppressor PTEN.

1 reference

12 December 2020

Dosage balance in gene regulation: biological implications

1 reference

12 December 2020

Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow

1 reference

12 December 2020

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

1 reference

12 December 2020

Impaired notch signaling promotes de novo squamous cell carcinoma formation

1 reference

12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

12 December 2020

10.1523/JNEUROSCI.2152-07.2007

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

274577

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

274577

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672827&resulttype=core&format=json

16 May 2020

2 references

Consolidated OpenCitations Corpus – April 2017

274577