SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas (Q39140068)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23764004%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas (English)

1 reference

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3 March 2020

2

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3 March 2020

Przemysław Juszczyński

3

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14

Todd Golub

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7

John G Doench

1 reference

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3 March 2020

6

Donna Neuberg

1 reference

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3 March 2020

15

Margaret A Shipp

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3 March 2020

author name string

Linfeng Chen

1

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3 March 2020

Jing Ouyang

4

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3 March 2020

Bjoern Chapuy

5

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Agata M Bogusz

8

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3 March 2020

Thomas M Habermann

9

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3 March 2020

Ahmet Dogan

10

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3 March 2020

Thomas E Witzig

11

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3 March 2020

Jeffery L Kutok

12

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3 March 2020

Scott J Rodig

13

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3 March 2020

publication date

1 June 2013

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3 March 2020

1 reference

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3 March 2020

volume

23

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3 March 2020

issue

6

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3 March 2020

page(s)

826-838

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Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma

3 March 2020

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Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

10 September 2017

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10 September 2017

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

10 September 2017

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The role of HRK gene in human cancer

10 September 2017

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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

10 September 2017

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FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells

10 September 2017

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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

10 September 2017

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

10 September 2017

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Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

10 September 2017

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FOXOs, cancer and regulation of apoptosis

10 September 2017

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SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

10 September 2017

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Lipid rafts and B cell signaling

10 September 2017

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Cholesterol reporter molecules

10 September 2017

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Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

10 September 2017

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SREBP in signal transduction: cholesterol metabolism and beyond

10 September 2017

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Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation

10 September 2017

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Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide.

10 September 2017

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes

10 September 2017

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Mechanisms of B-cell lymphoma pathogenesis

10 September 2017

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A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

10 September 2017

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Location is everything: lipid rafts and immune cell signaling.

10 September 2017

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10 September 2017

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

10 September 2017

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Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells

10 September 2017

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NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

10 September 2017

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10 September 2017

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SYK inhibition and response prediction in diffuse large B-cell lymphoma

10 September 2017

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10 September 2017

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A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

14 September 2017

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Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

14 September 2017

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NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

14 September 2017

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14 September 2017

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PI3 kinase signals BCR-dependent mature B cell survival

25 September 2017

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The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons

17 June 2018

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In vitro efficacy of tyrosine kinase inhibitors: SYK and BCR-ABL inhibitors in lymphomas.

17 June 2018

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Drug discovery: New Btk inhibitor holds promise.

21 August 2018

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FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

21 August 2018

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Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling

21 August 2018

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Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

21 August 2018

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

21 August 2018

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Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

21 August 2018

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Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23764004

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2013.05.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23764004%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23764004%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

23764004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23764004%20AND%20SRC:MED&resulttype=core&format=json