Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia (Q39142229)

9 September 2017

title

Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia (English)

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9 September 2017

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L L Yuan

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9 September 2017

A S Green

2

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S Bertoli

3

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F Grimal

4

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9 September 2017

V Mansat-De Mas

5

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C Dozier

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J Tamburini

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C Récher

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C Didier

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S Manenti

10

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9 September 2017

language of work or name

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10 June 2013

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9 September 2017

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9 September 2017

volume

28

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9 September 2017

issue

2

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9 September 2017

page(s)

293-301

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

9 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FLEU.2013.168

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

21 January 2018

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Chk1 promotes replication fork progression by controlling replication initiation

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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Chk1 is required for spindle checkpoint function.

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14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

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Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.168

Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition

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https://api.crossref.org/works/10.1038%2FLEU.2013.168

Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.168

Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

21 January 2018

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Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

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FLT3 in human hematologic malignancies

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

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The role of FLT3 in haematopoietic malignancies

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

21 January 2018

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For better or for worse: the role of Pim oncogenes in tumorigenesis

21 January 2018

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

21 January 2018

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The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells

21 January 2018

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

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Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin in vitro: role of Chk1 and Chk2 phosphorylation and caspase 3.

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Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

21 January 2018

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G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

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Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

21 January 2018

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Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype

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Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.168

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.168

Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML.

21 January 2018

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Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.168

Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.168

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

21 January 2018

1 reference

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Inhibition of Chk1 by activated PKB/Akt.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2013.168

1 reference

9 September 2017

1 reference