TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes (Q39155096)

9 September 2017

TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes (English)

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9 September 2017

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Almudena Porras

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Sonia Fernández-Veledo

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Sonia Fernández-Veledo

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Matilde R. Chacón

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Matilde R Chacón

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Joan Vendrell

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Joan Vendrell

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author name string

Ana Vázquez-Carballo

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9 September 2017

Victòria Ceperuelo-Mallafré

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9 September 2017

Elsa Maymó-Masip

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9 September 2017

Margarita Lorenzo

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9 September 2017

7 May 2013

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American Journal of Physiology - Endocrinology and Metabolism

9 September 2017

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9 September 2017

305

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9 September 2017

E101-12

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9 September 2017

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Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling

9 September 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Signal transduction by tumor necrosis factor receptors

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TNF-alpha and adipocyte biology

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Tumor necrosis factor-like weak inducer of apoptosis attenuates the action of insulin in hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Inflammatory mechanisms in obesity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: relationship with cardiovascular risk factors. a case-control study.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TWEAK attenuates the transition from innate to adaptive immunity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Non-canonical NF-κB signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Comparative expression analysis of isolated human adipocytes and the human adipose cell lines LiSa-2 and PAZ6.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00589.2012

10.1152/AJPENDO.00589.2012

21 January 2018

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9 September 2017

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