Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen (Q39179519)

9 September 2017

title

Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen (English)

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9 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28295428%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Jian Fang

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28295428%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Suowen Xu

series ordinal

3

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1 June 2020

publication date

16 February 2017

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Medicinal Research Reviews

9 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28295428%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

38

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28295428%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

1

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1 June 2020

page(s)

201-228

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Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association

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Recent insights into the cellular biology of atherosclerosis

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Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

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Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

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Nobel Prize for artemisinin brings phytotherapy into the spotlight.

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Tanshinone II-A: new perspectives for old remedies

21 January 2018

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The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review

21 January 2018

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New developments in the chemistry and biology of the bioactive constituents of Tanshen

21 January 2018

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Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension

21 January 2018

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Cardiovascular actions and therapeutic potential of tanshinone IIA.

21 January 2018

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Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis

21 January 2018

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Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use

21 January 2018

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Study on material base and action mechanism of compound Danshen dripping pills for treatment of atherosclerosis based on modularity analysis.

21 January 2018

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Naoxintong protects against atherosclerosis through lipid-lowering and inhibiting maturation of dendritic cells in LDL receptor knockout mice fed a high-fat diet

21 January 2018

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Lipid-lowering effects of Danhong injection on hyperlipidemia rats

21 January 2018

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Tanshinones: sources, pharmacokinetics and anti-cancer activities

21 January 2018

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Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits

21 January 2018

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Vascular reactivity screen of Chinese medicine danhong injection identifies Danshensu as a NO-independent but PGI2-mediated relaxation factor

21 January 2018

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Protocatechuic aldehyde inhibits TNF-α-induced fibronectin expression in human umbilical vein endothelial cells via a c-Jun N-terminal kinase dependent pathway

21 January 2018

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Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner

21 January 2018

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Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities.

21 January 2018

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Therapeutic effects of water soluble danshen extracts on atherosclerosis.

21 January 2018

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Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit

21 January 2018

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Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins.

21 January 2018

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Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet

21 January 2018

1 reference

Tanshinone IIA attenuates atherosclerosis in ApoE−/− mice through down-regulation of scavenger receptor expression

21 January 2018

1 reference

Anti-inflammatory effects of tanshinone IIA on atherosclerostic vessels of ovariectomized ApoE mice are mediated by estrogen receptor activation and through the ERK signaling pathway.

21 January 2018

1 reference

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.

21 January 2018

1 reference

Inhibition of experimental abdominal aortic aneurysm in a rat model by way of tanshinone IIA.

21 January 2018

1 reference

Vascular endothelium - Gatekeeper of vessel health.

21 January 2018

1 reference

Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders

21 January 2018

1 reference

The eNOS signalosome and its link to endothelial dysfunction.

21 January 2018

1 reference

Rho GTPases, statins, and nitric oxide

21 January 2018

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Modulation of endothelial nitric oxide by plant-derived products.

21 January 2018

1 reference

Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation

21 January 2018

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Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

21 January 2018

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Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging

21 January 2018

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Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension.

21 January 2018

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Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA.

21 January 2018

1 reference

Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease

21 January 2018

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Nitric oxide synthases: regulation and function

21 January 2018

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Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase

21 January 2018

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High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation

21 January 2018

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Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.

21 January 2018

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Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha

21 January 2018

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Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients.

21 January 2018

1 reference

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress

21 January 2018

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Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.

21 January 2018

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Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization.

21 January 2018

1 reference

The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.

21 January 2018

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The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression.

21 January 2018

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Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway.

21 January 2018

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Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells.

21 January 2018

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Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.

21 January 2018

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Tanshinone IIA inhibits endothelin-1 production in TNF-alpha-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis

21 January 2018

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Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism

21 January 2018

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Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells

21 January 2018

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Tanshinone IIA Attenuates H₂O₂ -induced injury in human umbilical vein endothelial cells.

21 January 2018

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Endothelial precursors in vascular repair

21 January 2018

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Protective effects of tanshinone ⅡA on endothelial progenitor cells injured by tumor necrosis factor-α.

21 January 2018

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Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells.

21 January 2018

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Angiogenesis: from plants to blood vessels

21 January 2018

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Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells.

21 January 2018

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Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway

21 January 2018

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Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice

21 January 2018

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Tanshinone IIA Prevents Rat Basilar Artery Smooth Muscle Cells Proliferation by Inactivation of PDK1 During the Development of Hypertension.

21 January 2018

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Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming α subunit

21 January 2018

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AMPK and vasculoprotection

21 January 2018

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Sodium tanshinone IIA silate inhibits high glucose-induced vascular smooth muscle cell proliferation and migration through activation of AMP-activated protein kinase

21 January 2018

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Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats

21 January 2018

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Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis

21 January 2018

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Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2/STAT3 signaling pathway.

21 January 2018

1 reference

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

21 January 2018

1 reference

Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways

21 January 2018

1 reference

Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway

21 January 2018

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Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells

21 January 2018

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Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

21 January 2018

1 reference

Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4-NF-κB Pathway

21 January 2018

1 reference

Scavenger receptors and non-coding RNAs: relevance in atherogenesis

21 January 2018

1 reference

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

21 January 2018

1 reference

Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages.

21 January 2018

1 reference

Macrophage death and defective inflammation resolution in atherosclerosis

21 January 2018

1 reference

Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase

21 January 2018

1 reference

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

21 January 2018

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OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

21 January 2018

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PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes.

21 January 2018

1 reference

A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1

21 January 2018

1 reference

Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome

21 January 2018

1 reference

Establishment of an interleukin-1β-induced inflammation-activated endothelial cell-smooth muscle cell-mononuclear cell co-culture model and evaluation of the anti-inflammatory effects of tanshinone IIA on atherosclerosis

21 January 2018

1 reference

Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

Inflammation and its resolution as determinants of acute coronary syndromes

21 January 2018

1 reference

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

21 January 2018

1 reference

Inflammation and immunity in diseases of the arterial tree: players and layers

21 January 2018

1 reference

Dendritic cells in atherosclerosis

21 January 2018

1 reference

Is thrombin a key player in the 'coagulation-atherogenesis' maze?

21 January 2018

1 reference

Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery

21 January 2018

1 reference

Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach.

21 January 2018

1 reference

Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway.

21 January 2018

1 reference

Tanshinone IIA promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphatidylinositol 3-kinase/Akt

21 January 2018

1 reference

Soluble epoxide hydrolase in atherosclerosis

21 January 2018

1 reference

Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis

21 January 2018

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Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation

21 January 2018

1 reference

Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration.

21 January 2018

1 reference

In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.

21 January 2018

1 reference

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

21 January 2018

1 reference

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

21 January 2018

1 reference

Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.

21 January 2018

1 reference

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

21 January 2018

1 reference

Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation

21 January 2018

1 reference

Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts

21 January 2018

1 reference

New Era of Lipid-Lowering Drugs

21 January 2018

1 reference

Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease

21 January 2018

1 reference

Recent advances in the pharmacological management of hypercholesterolaemia

21 January 2018

1 reference

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells

21 January 2018

1 reference

Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).

21 January 2018

1 reference

Cryptotanshinone inhibits oxidized LDL-induced adhesion molecule expression via ROS dependent NF-κB pathways

21 January 2018

1 reference

Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ.

21 January 2018

1 reference

Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells

21 January 2018

1 reference

Cryptotanshinone suppressed inflammatory cytokines secretion in RAW264.7 macrophages through inhibition of the NF-κB and MAPK signaling pathways

21 January 2018

1 reference

Cryptotanshinone inhibits LPS-induced proinflammatory mediators via TLR4 and TAK1 signaling pathway.

21 January 2018

1 reference

Tanshinone VI inhibits the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.

21 January 2018

1 reference

Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels

21 January 2018

1 reference

Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium

21 January 2018

1 reference

Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza

21 January 2018

1 reference

Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells.

21 January 2018

1 reference

Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge

21 January 2018

1 reference

Seeing the future of bioactive lipid drug targets

21 January 2018

1 reference

Induction of Heme Oxygenase-1 by Sodium 9-Hydroxyltanshinone IIA Sulfonate Derivative Contributes to Inhibit LPS-Mediated Inflammatory Response in Macrophages

21 January 2018

1 reference

Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake

21 January 2018

1 reference

Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages

21 January 2018

1 reference

Influence of nicotinic acid on serum cholesterol in man.

21 January 2018

1 reference

Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen).

21 January 2018

1 reference

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

21 January 2018

1 reference

Pharmacological tools for the development of traditional Chinese medicine

21 January 2018

1 reference

Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health.

21 January 2018

1 reference

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

21 January 2018

1 reference

Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model.

21 January 2018

1 reference

Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia

21 January 2018

1 reference

Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells

21 January 2018

1 reference

Insulin Resistance and Atherosclerosis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MED.21438

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28295428%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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