Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy (Q39209459)

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scientific article published on 17 January 2013

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English	Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy	scientific article published on 17 January 2013

Statements

scholarly article

1 reference

Europe PubMed Central

10 September 2017

Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy (English)

1 reference

Europe PubMed Central

10 September 2017

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neurodegeneration

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based on heuristic

inferred from title

Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

8

object named as

Sheng-Di Chen

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Europe PubMed Central

10 September 2017

author name string

Tian-Fang Jiang

1

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Europe PubMed Central

10 September 2017

Ying-Jie Zhang

2

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Europe PubMed Central

10 September 2017

Hai-Yan Zhou

3

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Europe PubMed Central

10 September 2017

Hong-Mei Wang

4

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Europe PubMed Central

10 September 2017

Li-Peng Tian

5

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Europe PubMed Central

10 September 2017

Jun Liu

6

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Europe PubMed Central

10 September 2017

Jian-Qing Ding

7

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Europe PubMed Central

10 September 2017

publication date

17 January 2013

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Europe PubMed Central

10 September 2017

Journal of Neuroimmune Pharmacology

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Europe PubMed Central

10 September 2017

8

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Europe PubMed Central

10 September 2017

1

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Europe PubMed Central

10 September 2017

356-369

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Europe PubMed Central

10 September 2017

https://scigraph.springernature.com/pub.10.1007/s11481-012-9431-7

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Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway

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https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Clinical studies with curcumin

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https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Knockdown survivin expression reduces the efficacy of curcumin treatment in hepatocellular carcinoma cells.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Autophagy and the integrated stress response

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin has neuroprotection effect on homocysteine rat model of Parkinson.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Autophagy: molecular mechanisms, physiological functions and relevance in human pathology

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

The role of the Atg1/ULK1 complex in autophagy regulation

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Autophagy fights disease through cellular self-digestion

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Molecular pathophysiology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Conformational equilibria in monomeric alpha-synuclein at the single-molecule level

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Autophagy: for better or for worse

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Mammalian autophagy: core molecular machinery and signaling regulation

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy.

1 reference

https://api.crossref.org/works/10.1007%2FS11481-012-9431-7

21 January 2018

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11481-012-9431-7

1 reference

Europe PubMed Central

10 September 2017

1 reference

Europe PubMed Central

10 September 2017

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