Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide. (Q39241268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984830%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide (English)

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14 February 2020

3

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14 February 2020

Angel Nadal

5

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14 February 2020

Anna Novials

6

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14 February 2020

author name string

Maud Soty

1

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14 February 2020

Montse Visa

2

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14 February 2020

María del Carmen Carmona

4

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14 February 2020

language of work or name

English

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publication date

7 October 2011

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Journal of Biological Chemistry

14 February 2020

published in

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14 February 2020

volume

286

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issue

47

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14 February 2020

page(s)

40857-40866

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Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction

14 February 2020

cites work

1 reference

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Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

10 September 2017

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Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

10 September 2017

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Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

10 September 2017

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Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

10 September 2017

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Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

10 September 2017

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10 September 2017

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Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism

10 September 2017

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How ATP inhibits the open K(ATP) channel

10 September 2017

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Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

10 September 2017

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Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

10 September 2017

1 reference

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Islet beta cell failure in type 2 diabetes

10 September 2017

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Insulin resistance and pancreatic beta cell failure

10 September 2017

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

10 September 2017

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Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

10 September 2017

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Mitochondrial dysfunction and type 2 diabetes

10 September 2017

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Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule

10 September 2017

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

10 September 2017

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Mitochondrial function in normal and diabetic beta-cells

10 September 2017

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ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

10 September 2017

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Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells

10 September 2017

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Molecular biology of adenosine triphosphate-sensitive potassium channels

10 September 2017

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ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies

10 September 2017

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The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

10 September 2017

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Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy

10 September 2017

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

10 September 2017

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Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy

10 September 2017

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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

10 September 2017

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Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin

10 September 2017

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Islet amyloid polypeptide acts on glucose- stimulated beta cells to reduce voltage-gated calcium channel activation, intracellular Ca(2+) concentration, and insulin secretion

14 September 2017

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Measuring mitochondrial bioenergetics in INS-1E insulinoma cells

14 September 2017

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Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis

14 September 2017

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Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

14 September 2017

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Use of recombinant adenovirus for metabolic engineering of mammalian cells.

14 September 2017

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Effects of glucose and amino acids on free ADP in betaHC9 insulin-secreting cells

14 September 2017

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Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

25 September 2017

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

25 September 2017

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Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220453

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

15 June 2018

1 reference

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Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets

15 June 2018

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15 June 2018

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Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling.

15 June 2018

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Amyloid oligomers in diabetic and nondiabetic human pancreas

21 August 2018

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Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

21 August 2018

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21 August 2018

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21 August 2018

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21 August 2018

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Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes

21 August 2018

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Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice.

21 August 2018

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Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes

21 August 2018

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12 December 2020

Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets

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12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

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12 December 2020

Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation

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12 December 2020

Regulation of islet amyloid polypeptide in human pancreatic islets

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12 December 2020

Aging and insulin secretion

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12 December 2020

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1 reference

12 December 2020

Inhibitory effect of amylin (islet amyloid polypeptide) on insulin response to non-glucose stimuli. Study in perfused rat pancreas

1 reference

12 December 2020

Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

12 December 2020

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12 December 2020

Mutations in ATP-Sensitive K+ Channel Genes Cause Transient Neonatal Diabetes and Permanent Diabetes in Childhood or Adulthood

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.232801

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984830%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984830%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

21984830

1 reference