A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo (Q39251935)

10 September 2017

title

A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo (English)

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10 September 2017

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C Eberlein

1

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10 September 2017

J Kendrew

2

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10 September 2017

K McDaid

3

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10 September 2017

A Alfred

4

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10 September 2017

J S Kang

5

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10 September 2017

V N Jacobs

6

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10 September 2017

S J Ross

7

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10 September 2017

C Rooney

8

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N R Smith

9

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10 September 2017

J Rinkenberger

10

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A Cao

11

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10 September 2017

A Churchman

12

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10 September 2017

J F Marshall

13

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10 September 2017

H M Weir

14

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10 September 2017

V Bedian

15

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10 September 2017

D C Blakey

16

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10 September 2017

I N Foltz

17

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10 September 2017

S T Barry

18

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10 September 2017

language of work or name

English

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publication date

29 October 2012

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10 September 2017

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10 September 2017

volume

32

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10 September 2017

issue

37

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10 September 2017

page(s)

4406-4416

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https://scigraph.springernature.com/pub.10.1038/onc.2012.460

10 September 2017

exact match

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cites work

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands

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Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas

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Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro.

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Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma

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A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer

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The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.

21 January 2018

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The 120 kDa cell-binding fragment of fibronectin up-regulates migration of alphavbeta6-expressing cells by increasing matrix metalloproteinase-2 and -9 secretion.

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AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.

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Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade

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alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation

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Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.

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Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6

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Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

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Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

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Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells

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Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

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Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

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Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis

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Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

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Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

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Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch

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Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

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Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis

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A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities

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PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells

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Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus

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Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

21 January 2018

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TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation

21 January 2018

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Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells

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MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8.

21 January 2018

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Gene-Expression Profiles in Hereditary Breast Cancer

21 January 2018

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21 January 2018

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

21 January 2018

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HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

21 January 2018

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Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer

21 January 2018

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Direct integrin alphavbeta6-ERK binding: implications for tumour growth

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.460

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.460

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.460

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.460

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Dimensions Publication ID

10 September 2017

1035620730

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