TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation (Q42446503)

31 October 2017

TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation (English)

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31 October 2017

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31 October 2017

Y M Fleming

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31 October 2017

G J Ferguson

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L C Spender

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J Larsson

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S Karlsson

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B W Ozanne

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G J Inman

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31 October 2017

language of work or name

English

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publication date

15 December 2008

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28

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983-993

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7

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https://scigraph.springernature.com/pub.10.1038/onc.2008.449

31 October 2017

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cites work

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

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TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.449

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Bone morphogenetic proteins

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.449

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.449

Rho GTPases: biochemistry and biology

31 March 2020

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Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

31 March 2020

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Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

31 March 2020

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Smad transcription factors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Non-Smad TGF-beta signals

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

31 March 2020

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Invasion is a genetic program regulated by transcription factors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

A role for Rho in Ras transformation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

The two faces of transforming growth factor beta in carcinogenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Transformation mediated by RhoA requires activity of ROCK kinases

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

31 March 2020

RHO-GTPases and cancer

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

TGF-beta signaling: positive and negative effects on tumorigenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.449

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.449

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Dimensions Publication ID

31 October 2017

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