Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants (Q39263753)

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English	Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants	scientific article

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scholarly article

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Europe PubMed Central

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10 September 2017

Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants (English)

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Europe PubMed Central

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10 September 2017

Mónica Bequet-Romero

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Mónica Bequet-Romero

5

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Pedro Luis Ramos

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Pedro Luis Ramos

13

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author name string

Meilyn Rodríguez

1

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10 September 2017

Lincidio Pérez

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10 September 2017

Jorge V Gavilondo

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10 September 2017

Greta Garrido

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10 September 2017

Ignacio Hernández

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10 September 2017

Vivian Huerta

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10 September 2017

Gleysin Cabrera

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10 September 2017

Marlene Pérez

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Osmani Ramos

10

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10 September 2017

René Leyva

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10 September 2017

Mariela León

12

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10 September 2017

Ada Triguero

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Abel Hernández

15

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10 September 2017

Belinda Sánchez

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10 September 2017

Marta Ayala

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10 September 2017

Jeny Soto

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10 September 2017

Ernesto González

19

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10 September 2017

Osmani Mendoza

20

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10 September 2017

Kenia Tiel

21

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10 September 2017

Merardo Pujol

22

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10 September 2017

publication date

10 October 2012

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10 September 2017

Plant Biotechnology Journal

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10 September 2017

11

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10 September 2017

1

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10 September 2017

53-65

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10 September 2017

The impact of glycosylation on the biological function and structure of human immunoglobulins.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Strategies and challenges for the next generation of therapeutic antibodies

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations.

1 reference

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Nonselective and efficient fluorescent labeling of glycans using 2-amino benzamide and anthranilic acid

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Seed-based expression systems for plant molecular farming

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients

1 reference

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Treatment of NSCLC patients with an EGF-based cancer vaccine: report of a Phase I trial

1 reference

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21 January 2018

Production of antibodies in plants: status after twenty years

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

The state of antibody therapy

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

GMP issues for recombinant plant-derived pharmaceutical proteins.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Intermediate organelles of the plant secretory pathway: identity and function.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-derived vaccines and other therapeutics produced in contained systems

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profile

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-specific glycosylation patterns in the context of therapeutic protein production.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-Produced Trastuzumab Inhibits the Growth of HER2 Positive Cancer Cells

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Production of antibodies in transgenic plants

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Role of genetic factors and environmental conditions in recombinant protein production for molecular farming

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

The production of biopharmaceuticals in plant systems

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Function and glycosylation of plant-derived antiviral monoclonal antibody

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Inhibition of tumor growth by plant-derived mAb.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Transient expression systems for plant-derived biopharmaceuticals

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-made trastuzumab (herceptin) inhibits HER2/Neu+ cell proliferation and retards tumor growth

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Neonatal Fc receptor: from immunity to therapeutics

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Comparative analysis of binding affinities to epidermal growth factor receptor of monoclonal antibodies nimotuzumab and cetuximab using different experimental animal models.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Tyrosine kinase inhibition: an approach to drug development

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Structural characterization of N-linked oligosaccharides on monoclonal antibody Nimotuzumab through process development

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Biodistribution of 99mTc-labeled anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody h-R3 in a xenograft model of human lung adenocarcinoma

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Fcgamma receptors: old friends and new family members

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Advances in plant molecular farming

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-made pharmaceuticals: leading products and production platforms.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Expression of a single-chain Fv antibody fragment specific for the hepatitis B surface antigen in transgenic tobacco plants

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Expression and characterization of an anti-(hepatitis B surface antigen) glycosylated mouse antibody in transgenic tobacco (Nicotiana tabacum) plants and its use in the immunopurification of its target antigen

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Treatment of malignant, non-resectable, epithelial origin esophageal tumours with the humanized anti-epidermal growth factor antibody nimotuzumab combined with radiation therapy and chemotherapy.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

FcRn: the neonatal Fc receptor comes of age.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-produced vaccines: promise and reality

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Double acylation for identification of amino-terminal peptides of proteins isolated by polyacrylamide gel electrophoresis.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Active antimetastatic immunotherapy in Lewis lung carcinoma with self EGFR extracellular domain protein in VSSP adjuvant

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plants as bioreactors: Recent developments and emerging opportunities

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

FcgammaR: The key to optimize therapeutic antibodies?

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Approaches to achieve high-level heterologous protein production in plants

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Plant-derived mouse IgG monoclonal antibody fused to KDEL endoplasmic reticulum-retention signal is N-glycosylated homogeneously throughout the plant with mostly high-mannose-type N-glycans

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Large-scale purification of an antibody directed against hepatitis B surface antigen from transgenic tobacco plants.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Recovery and purification of plant-made recombinant proteins

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

A dose-escalation phase I trial of nimotuzumab, an antibody against the epidermal growth factor receptor, in patients with advanced solid malignancies.

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1111%2FPBI.12006

21 January 2018

Identifiers

10.1111/PBI.12006

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

ResearchGate publication ID

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