A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma (Q39276419)

10 September 2017

A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma (English)

1 reference

10 September 2017

Paola Falletta

2

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Veronique Delmas

object named as

Veronique Delmas

4

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Colin R. Goding

object named as

Colin R Goding

5

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author name string

Elise Bonvin

1

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10 September 2017

Heather Shaw

3

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10 September 2017

language of work or name

English

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publication date

17 September 2012

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Molecular and Cellular Biology

10 September 2017

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10 September 2017

32

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10 September 2017

22

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10 September 2017

4674-4683

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describes a project that uses

10 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3486186/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The role of mitogen- and stress-activated protein kinase pathways in melanoma

10 September 2017

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10 September 2017

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10 September 2017

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Cancer stem cells versus phenotype-switching in melanoma

10 September 2017

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

10 September 2017

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Fifteen-year quest for microphthalmia-associated transcription factor target genes

10 September 2017

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10 September 2017

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Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination

10 September 2017

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The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

10 September 2017

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Phosphatidylinositol-3-kinase as a therapeutic target in melanoma

10 September 2017

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Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease

10 September 2017

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POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis

10 September 2017

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

10 September 2017

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Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

10 September 2017

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In vivo switching of human melanoma cells between proliferative and invasive states

10 September 2017

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Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

10 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Pax3 functions at a nodal point in melanocyte stem cell differentiation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

10 September 2017

1 reference

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Deregulated Akt3 activity promotes development of malignant melanoma

10 September 2017

1 reference

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The Brn-2 transcription factor links activated BRAF to melanoma proliferation

10 September 2017

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Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin

10 September 2017

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PTEN signaling pathways in melanoma

10 September 2017

1 reference

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Mutations of the BRAF gene in human cancer

10 September 2017

1 reference

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Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Direct regulation of the Microphthalmia promoter by Sox10 links Waardenburg-Shah syndrome (WS4)-associated hypopigmentation and deafness to WS2.

10 September 2017

1 reference

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Epistatic relationship between Waardenburg syndrome genes MITF and PAX3

10 September 2017

1 reference

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Molecular basis of splotch and Waardenburg Pax-3 mutations

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

10 September 2017

1 reference

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Differential PAX3 functions in normal skin melanocytes and melanoma cells.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Lymphoid enhancer factor-1 mediates loading of Pax3 to a promoter harbouring lymphoid enhancer factor-1 binding sites resulting in enhancement of transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

PAX3 expression in primary melanomas and nevi

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Regulation of murine TGFbeta2 by Pax3 during early embryonic development.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

PI3-kinase subunits are infrequent somatic targets in melanoma.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3486186

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

2 December 2018

1 reference

12 December 2020

Pax3 target gene recognition occurs through distinct modes that are differentially affected by disease-associated mutations.

1 reference

12 December 2020

Mutations of PIK3CA are rare in cutaneous melanoma

1 reference

12 December 2020

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

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12 December 2020

Identifiers

DOI

10.1128/MCB.01067-12

1 reference

10 September 2017

1 reference

10 September 2017

PubMed publication ID

22988297

1 reference