Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions (Q39285542)

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scientific article published on 5 September 2012

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English	Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions	scientific article published on 5 September 2012

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scholarly article

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PubMed publication ID

10 September 2017

Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions (English)

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10 September 2017

non-small-cell lung carcinoma

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author name string

Hongqin Zhuang

1

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10 September 2017

Weiwei Jiang

2

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10 September 2017

Xiangyu Zhang

3

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10 September 2017

Fan Qiu

4

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10 September 2017

Ziyi Gan

5

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10 September 2017

Wei Cheng

6

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10 September 2017

Jing Zhang

7

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10 September 2017

Shengwen Guan

8

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10 September 2017

Bo Tang

9

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10 September 2017

Qilai Huang

10

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10 September 2017

Xinhua Wu

11

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10 September 2017

Xiaofeng Huang

12

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10 September 2017

Wenhui Jiang

13

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10 September 2017

Qingang Hu

14

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10 September 2017

Min Lu

15

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10 September 2017

Zi-Chun Hua

16

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10 September 2017

publication date

5 September 2012

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10 September 2017

Journal of Molecular Medicine

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10 September 2017

91

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10 September 2017

2

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10 September 2017

219-235

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10 September 2017

https://scigraph.springernature.com/pub.10.1007/s00109-012-0947-3

0 references

Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

On the TRAIL to apoptosis

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

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Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.

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21 January 2018

Escaping cell death: survival proteins in cancer

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21 January 2018

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

RNA interference

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro

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STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival

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Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis.

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Apo2L/TRAIL and its death and decoy receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Post-translational modification of p53 in tumorigenesis

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.

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21 January 2018

To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

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https://api.crossref.org/works/10.1007%2FS00109-012-0947-3

21 January 2018

Current insights into the regulation of programmed cell death by NF-kappaB.

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21 January 2018

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

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21 January 2018

JNK signaling in apoptosis

1 reference

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21 January 2018

p53 upregulates death receptor 4 expression through an intronic p53 binding site

1 reference

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21 January 2018

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

1 reference

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21 January 2018

Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and nonpulmonary cancer cell lines in athymic nude mice

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https://pubmed.ncbi.nlm.nih.gov/22948392

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International comparisons of survival from lung cancer: pitfalls and warnings

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Activation of c-Jun N-terminal kinases by ribotoxic stresses.

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The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro

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p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha

1 reference

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α-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis

1 reference

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12 December 2020

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10.1007/S00109-012-0947-3

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Europe PubMed Central

PubMed publication ID

10 September 2017

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10 September 2017

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