Apo2L/TRAIL and its death and decoy receptors (Q34532325)

2 August 2017

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title

Apo2L/TRAIL and its death and decoy receptors (English)

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2 August 2017

LeBlanc HN

1

1 reference

PubMed ID

12655296

2 August 2017

Ashkenazi A

series ordinal

2

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2 August 2017

1 January 2003

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Cell Death & Differentiation

2 August 2017

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2 August 2017

10

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2 August 2017

66-75

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2 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401187

2 August 2017

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cites work

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Identification and characterization of a new member of the TNF family that induces apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Safety and antitumor activity of recombinant soluble Apo2 ligand

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

The receptor for the cytotoxic ligand TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Characterization of two receptors for TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Avoiding premature apoptosis of normal epidermal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Inhibition of fas death signals by FLIPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

NF-kappaB at the crossroads of life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Activation of protein kinase C inhibits TRAIL-induced caspases activation, mitochondrial events and apoptosis in a human leukemic T cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Molecular cross-talk between the TRAIL and interferon signaling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Measles virus induces functional TRAIL production by human dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Apoptosis control by death and decoy receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401187

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401187

1 reference

2 August 2017

1 reference

PubMed ID

12655296