A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart. (Q39308907)

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8 February 2020

title

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart (English)

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8 February 2020

4

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Dmitry Guschin

6

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Philip D Gregory

18

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Edward J Rebar

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author name string

H Steve Zhang

1

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8 February 2020

Dingang Liu

2

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Yan Huang

3

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Reed Hickey

5

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Haili Su

7

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Ion S Jovin

8

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Mike Kunis

9

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8 February 2020

Sarah Hinkley

10

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8 February 2020

Yuxin Liang

11

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Linda Hinh

12

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S Kaye Spratt

13

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Casey C Case

14

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Barbara E Ehrlich

16

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Barbara Ehrlich

17

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Frank J Giordano

19

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8 February 2020

publication date

24 July 2012

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8 February 2020

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volume

20

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issue

8

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page(s)

1508-1515

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

8 February 2020

cites work

1 reference

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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines

11 September 2017

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Zinc-finger-based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa

11 September 2017

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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.

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Targeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function

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Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein

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A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids

11 September 2017

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11 September 2017

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A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

11 September 2017

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siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

11 September 2017

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11 September 2017

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Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

11 September 2017

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Phospholamban: a crucial regulator of cardiac contractility

11 September 2017

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Expression profiling reveals off-target gene regulation by RNAi

11 September 2017

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Drug discovery with engineered zinc-finger proteins

11 September 2017

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siRNAs can function as miRNAs

11 September 2017

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Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

11 September 2017

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Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation

11 September 2017

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Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors

11 September 2017

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Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure

11 September 2017

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Design and selection of novel Cys2His2 zinc finger proteins

11 September 2017

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Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units

11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation

11 September 2017

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An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

11 September 2017

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14 September 2017

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17 June 2018

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Adenovirus-mediated apo(a)-antisense-RNA expression efficiently inhibits apo(a) synthesis in vitro and in vivo

2 December 2018

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Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility

17 June 2018

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Adenovirus-Mediated Gene Transfer Reconstitutes Depressed Sarcoplasmic Reticulum Ca 2+ -ATPase Levels and Shortens Prolonged Cardiac Myocyte Ca 2+ Transients

17 June 2018

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Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy

17 June 2018

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21 August 2018

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Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system

21 August 2018

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Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals

21 August 2018

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Reduced sarcoplasmic reticulum Ca2+ -ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium.

21 August 2018

1 reference

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Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

21 August 2018

1 reference

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Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury.

21 August 2018

1 reference

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Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

21 August 2018

1 reference

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Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

21 August 2018

1 reference

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Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy

21 August 2018

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12 December 2020

Retrograde coronary perfusion: a superior route to deliver therapeutics to the heart?*

1 reference

12 December 2020

Role of cardiac renin-angiotensin system in the development of pressure-overload left ventricular hypertrophy in rats with abdominal aortic constriction

1 reference

12 December 2020

Calcium and heart failure: the cycle game

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12 December 2020

Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy

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12 December 2020

Widespread regional myocardial transfection by plasmid encoding Del-1 following retrograde coronary venous delivery

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12 December 2020

Identifiers

DOI

10.1038/MT.2012.80

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22828502%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

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8 February 2020

PubMed publication ID

22828502

1 reference

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