Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors. (Q39335098)

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English	Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.	scientific article

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4 February 2020

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors (English)

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4 February 2020

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tumor progression

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Xia Ke

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4 February 2020

Fei Fei

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4 February 2020

Yanke Chen

3

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4 February 2020

Li Xu

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4 February 2020

Zheng Zhang

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4 February 2020

Qichao Huang

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4 February 2020

Hongxin Zhang

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4 February 2020

Hushan Yang

8

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4 February 2020

Zhinan Chen

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4 February 2020

Jinliang Xing

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4 February 2020

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7 June 2012

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4 February 2020

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4 February 2020

33

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4 February 2020

8

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4 February 2020

1598-1607

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4 February 2020

MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen(es) and the hypoxia-inducible factor-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-responsive transcription factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF hydroxylation and the mammalian oxygen-sensing pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hypoxia-inducible factors in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of EMMPRIN after permanent focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance and application of anti-malignant hepatoma MAb HAb18 in radioimmunal diagnosis of human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial lactate oxidation complex and an adaptive role for lactate production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor metabolism: cancer cells give and take lactate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy metabolism in tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia, HIF1 and glucose metabolism in the solid tumour

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factors, stem cells, and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic alterations of metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/CARCIN/BGS196

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4 February 2020

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4 February 2020

PubMed publication ID

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Europe PubMed Central

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4 February 2020

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