Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway (Q29617805)

Europe PubMed Central

title

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway (English)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18498744

30 April 2017

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Ratcliffe PJ

2

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author name string

Kaelin WG Jr

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18498744

30 April 2017

language of work or name

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30 April 2017

publication date

23 May 2008

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30 April 2017

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30 April 2017

volume

30

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18498744

30 April 2017

page(s)

393-402

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30 April 2017

issue

4

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

30 April 2017

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability

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Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia

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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

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Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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Von Hippel-Lindau disease.

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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Proline hydroxylation and gene expression

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Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

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Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells.

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Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

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The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

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Oxygen sensing by HIF hydroxylases

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Hypoxia-inducible factors, stem cells, and cancer

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.

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Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

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Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

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HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

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Harnessing hypoxic adaptation to prevent, treat, and repair stroke.

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Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha.

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Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

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Molecular pathways in renal cell carcinoma--rationale for targeted treatment

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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A microRNA signature of hypoxia

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The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

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Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

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Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

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Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

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12 October 2022

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

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SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

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12 October 2022

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Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance

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12 October 2022

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Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

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12 October 2022

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia

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12 October 2022

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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12 October 2022

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Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site.

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12 October 2022

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The hypoxic response of tumors is dependent on their microenvironment.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

HIF-dependent antitumorigenic effect of antioxidants in vivo

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12 October 2022

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Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MOLCEL.2008.04.009

Identifiers

DOI

10.1016/J.MOLCEL.2008.04.009

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18498744

30 April 2017

Consolidated OpenCitations Corpus – April 2017

12470

12470

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18498744

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017